INT261826

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADRA2B) cell-cell signaling (ADRA2B) signal transducer activity (ADRA2B)
Anatomy Link Frequency
head 1
ADRA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 1 99.44 Very High Very High Very High
Pain 92 63.12 Quite High
Neuropathic pain 7 59.28 Quite High
medulla 3 56.72 Quite High
Spinal cord 7 56.20 Quite High
nociceptor 46 50.00 Quite Low
qutenza 23 50.00 Quite Low
depression 1 48.80 Quite Low
neuropeptide release 1 41.68 Quite Low
cerebral cortex 2 37.36 Quite Low
Disease Link Frequency Relevance Heat
Urticaria 1 73.68 Quite High
Coronary Heart Disease 1 71.40 Quite High
Pain 96 63.12 Quite High
Neuropathic Pain 21 59.28 Quite High
Pre-term Labor 1 50.12 Quite High
Hypertension 2 49.36 Quite Low
Depression 1 48.80 Quite Low
Anxiety Disorder 2 48.32 Quite Low
Nociception 17 41.60 Quite Low
Targeted Disruption 23 22.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Translocation of TRPV2 from intracellular locations to plasma membrane required for its activation is regulated by insulin-like growth factor-I (IGF-I) [99]; A-kinase anchoring proteins (AKAP)/cAMP/protein kinase A (PKA) mediated phosphorylation [197]; G-protein coupled receptor ligands like neuropeptide head activator (HA) via phosphatidylinositol 3-kinase (PI3-K) andof the Ca2+/calmodulin-dependent kinase (CAMK) signaling [17].
Phosphorylation (phosphorylation) of G-protein coupled receptor in head associated with neuropeptide
1) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.38 Pain Relevance 0.29

General Comments

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