INT261828

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv2) extracellular space (Igf1) extracellular region (Igf1)
plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
Anatomy Link Frequency
head 4
Igf1 (Mus musculus)
Trpv2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 94.28 High High
Neuropathic pain 14 68.48 Quite High
medulla 6 65.92 Quite High
Spinal cord 14 65.40 Quite High
depression 2 58.00 Quite High
Pain 184 52.80 Quite High
neuropeptide release 2 50.88 Quite High
nociceptor 92 50.00 Quite Low
qutenza 46 50.00 Quite Low
cerebral cortex 4 46.56 Quite Low
Disease Link Frequency Relevance Heat
Urticaria 2 82.88 Quite High
Coronary Heart Disease 2 80.60 Quite High
Neuropathic Pain 42 68.48 Quite High
Pre-term Labor 2 59.32 Quite High
Hypertension 4 58.56 Quite High
Depression 2 58.00 Quite High
Anxiety Disorder 4 57.52 Quite High
Pain 192 52.80 Quite High
Nociception 34 39.68 Quite Low
Stress Incontinence 2 19.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Translocation of TRPV2 from intracellular locations to plasma membrane required for its activation is regulated by insulin-like growth factor-I (IGF-I) [99]; A-kinase anchoring proteins (AKAP)/cAMP/protein kinase A (PKA) mediated phosphorylation [197]; G-protein coupled receptor ligands like neuropeptide head activator (HA) via phosphatidylinositol 3-kinase (PI3-K) andof the Ca2+/calmodulin-dependent kinase (CAMK) signaling [17].
insulin-like growth factor-I Regulation (regulated) of Localization (Translocation) of TRPV2 in head associated with neuropeptide
1) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.52 Pain Relevance 0.29
Translocation of TRPV2 from intracellular locations to plasma membrane required for its activation is regulated by insulin-like growth factor-I (IGF-I) [99]; A-kinase anchoring proteins (AKAP)/cAMP/protein kinase A (PKA) mediated phosphorylation [197]; G-protein coupled receptor ligands like neuropeptide head activator (HA) via phosphatidylinositol 3-kinase (PI3-K) andof the Ca2+/calmodulin-dependent kinase (CAMK) signaling [17].
IGF-I Regulation (regulated) of Localization (Translocation) of TRPV2 in head associated with neuropeptide
2) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.52 Pain Relevance 0.29

General Comments

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