INT261831

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.26
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) extracellular matrix organization (Hspg2)
protein complex (Mapk1) cytoplasm (Mapk1) cytosol (Mapk1)
Mapk1 (Mus musculus)
Hspg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cold hyperalgesia 4 98.52 Very High Very High Very High
Thermal hyperalgesia 18 96.64 Very High Very High Very High
nociceptor 92 96.12 Very High Very High Very High
Eae 10 95.64 Very High Very High Very High
Nerve growth factor 12 94.96 High High
Hyperalgesia 32 92.36 High High
bradykinin 10 89.96 High High
agonist 64 85.88 High High
Kappa opioid receptor 2 75.36 Quite High
Antinociceptive 2 71.40 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 54 98.52 Very High Very High Very High
Inflammatory Pain 8 95.64 Very High Very High Very High
Hypersensitivity 6 88.16 High High
Targeted Disruption 46 57.56 Quite High
Cancer 8 54.88 Quite High
Systemic Lupus Erythematosus 2 50.60 Quite High
Demyelinating Disease 2 50.16 Quite High
Arthritis 4 49.36 Quite Low
Airway Obstruction 2 40.92 Quite Low
Cough 6 40.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPA1 is potentiated by extracellular signal-regulated protein kinase (ERK) and PLC disinhibition of PIP2 via proteinase activated receptor (PAR)-2 mediated activation in models of thermal hyperalgesia and inflammatory pain [42, 103, 135].
extracellular signal-regulated protein kinase Negative_regulation (disinhibition) of PLC associated with eae and thermal hyperalgesia
1) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.68 Pain Relevance 0.73
TRPA1 is potentiated by extracellular signal-regulated protein kinase (ERK) and PLC disinhibition of PIP2 via proteinase activated receptor (PAR)-2 mediated activation in models of thermal hyperalgesia and inflammatory pain [42, 103, 135].
ERK Negative_regulation (disinhibition) of PLC associated with eae and thermal hyperalgesia
2) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.58 Pain Relevance 0.69

General Comments

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