INT261834

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Itpr3, Prkca) cytoplasm (Itpr3, Prkca) nucleus (Itpr3, Prkca)
nucleoplasm (Itpr3) mitochondrion (Prkca) transport (Itpr3)
Itpr3 (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 10 100.00 Very High Very High Very High
nociceptor 46 85.32 High High
long-term potentiation 63 82.08 Quite High
Nerve growth factor 6 79.80 Quite High
bradykinin 5 78.84 Quite High
Inflammatory mediators 1 75.80 Quite High
Glutamate 6 72.92 Quite High
Pain 92 63.88 Quite High
Cannabinoid receptor 1 50.36 Quite High
qutenza 23 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 75.40 Quite High
Ganglion Cysts 3 74.32 Quite High
Disease 20 64.32 Quite High
Pain 96 63.88 Quite High
Nociception 17 53.52 Quite High
Hypersensitivity 3 8.16 Low Low
Inflammatory Pain 4 7.48 Low Low
Hyperalgesia 27 5.00 Very Low Very Low Very Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Neuropathic Pain 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gq/11 subunits' downstream signaling bifurcates into the production of IP3 and DAG, which has been shown to promote Ca2+ release from intracellular stores, activate PKC, and locally deplete PIP2 levels (Delmas and Brown, 2005).
IP3 Positive_regulation (activate) of PKC
1) Confidence 0.01 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.07 Pain Relevance 0.17
PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) and hydrolysis of PIP2 also releases inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which activate PKC, leading to TRPV1 phosphorylation [83].
IP3 Positive_regulation (activate) of PKC associated with kinase c
2) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.26 Pain Relevance 0.60

General Comments

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