INT261845

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) transport (Trpa1) signal transduction (NGF)
extracellular space (NGF) extracellular region (NGF) transmembrane transport (Trpa1)
Anatomy Link Frequency
nociceptors 1
NGF (Homo sapiens)
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 6 100.00 Very High Very High Very High
nociceptor 46 99.84 Very High Very High Very High
Cold hyperalgesia 2 97.68 Very High Very High Very High
Hyperalgesia 16 97.52 Very High Very High Very High
bradykinin 5 95.12 Very High Very High Very High
agonist 32 91.04 High High
Thermal hyperalgesia 9 78.48 Quite High
Antinociceptive 1 76.56 Quite High
Eae 5 76.48 Quite High
Kappa opioid receptor 1 60.56 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 27 97.52 Very High Very High Very High
Hypersensitivity 3 93.32 High High
Inflammatory Pain 4 76.48 Quite High
Targeted Disruption 23 62.72 Quite High
Systemic Lupus Erythematosus 1 55.76 Quite High
Demyelinating Disease 1 55.32 Quite High
Arthritis 2 54.52 Quite High
Cancer 4 53.80 Quite High
Airway Obstruction 1 46.08 Quite Low
Cough 3 45.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noguchi and colleagues showed that an increase in NGF-induced TRPA1 in nociceptors via p38 MAPK activation was necessary for cold hyperalgesia [134, 155].
NGF Positive_regulation (induced) of TRPA1 in nociceptors associated with hyperalgesia, cold hyperalgesia, nerve growth factor and nociceptor
1) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.73 Pain Relevance 0.71

General Comments

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