INT261849

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 1.15
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
neurons 4
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 60 99.68 Very High Very High Very High
agonist 103 98.48 Very High Very High Very High
antagonist 63 97.12 Very High Very High Very High
Glutamate 77 95.24 Very High Very High Very High
nMDA receptor 90 93.44 High High
addiction 27 71.52 Quite High
Eae 7 56.36 Quite High
Hippocampus 6 12.64 Low Low
withdrawal 36 5.00 Very Low Very Low Very Low
cocaine 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 38 92.96 High High
Death 81 90.24 High High
Disease 43 89.56 High High
Apoptosis 157 76.32 Quite High
Tauopathy 1 73.20 Quite High
Drug Induced Neurotoxicity 2 61.04 Quite High
Disease Progression 2 56.00 Quite High
Hyperinsulinism 1 48.76 Quite Low
Neurodegenerative Disease 20 47.20 Quite Low
Toxicity 7 27.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In subsequent experiments we analyzed in more detail the intracellular signalling mechanism of GSK3 phosphorylation induced by the three stimuli, employing inhibitors of different signal transducing proteins that can be upstream of GSK3.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GSK3
1) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0
The activation of both these nucleotide receptors resulted in an increase in the phosphorylation levels of GSK3 at specific Ser residues that were associated with the inhibition of its catalytic activity [9].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GSK3
2) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
Acetaminophen administration increased the abundance of phosphorylated GSK-3 by 170.5% when compared to age-matched control (P<0.05).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of GSK-3 associated with paracetamol
3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.09 Pain Relevance 0.53
M, 20 min) was able to abolish BDNF-induced increase in GSK3 phosphorylation, but only partially affected the BzATP and NMDA-mediated effects (Fig. 1b).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GSK3
4) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0
M) and BDNF (50 ng/ml) were able to induce significant increases in GSK3 phosphorylation over basal levels.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of GSK3
5) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.13
Nevertheless, P2X7-induced GSK3 phosphorylation occurred through a PKC-dependent pathway.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GSK3
6) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.35 Pain Relevance 0.08
In the case of NMDA and BzATP the increase percentages in GSK3 phosphorylation were in the same range, being always slightly higher for NMDA.Fig. 1GSK3 phosphorylation induced by BzATP, NMDA and BDNF in granule neurons. a Time-course of GSK3 phosphorylation.
Positive_regulation (percentages) of Phosphorylation (phosphorylation) of GSK3 in neurons
7) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.10
We demonstrated that BzATP-induced GSK3 phosphorylation was dependent on extracellular calcium, and sensitive to P2X7 specific antagonists [12].
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GSK3 associated with antagonist
8) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.14
Figure 2a shows the dose–response curve for NMDA-induced GSK3 phosphorylation performed in the absence and presence of co-stimulation with the nucleotide agonist BzATP.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GSK3 associated with agonist
9) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.16
BDNF was the most potent at inducing GSK3 phosphorylation, which was also dependent on PI3K.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of GSK3
10) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Abstract Doc Link PMC2858808 Disease Relevance 0.09 Pain Relevance 0.08
The activation of these receptors in granule neurons led to a sustained pattern of GSK3 phosphorylation that was mainly PKC-dependent.
Positive_regulation (led) of Phosphorylation (phosphorylation) of GSK3 in neurons
11) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Abstract Doc Link PMC2858808 Disease Relevance 0.08 Pain Relevance 0.07
PKC inhibition also blocked the BzATP-mediated increase in GSK3 phosphorylation, but a residual effect seemed to persist after NMDA stimulation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GSK3
12) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
It was reported that memantine caused an increase in vivo in phosphorylation of GSK-3, which inhibits its function and could thereby reduce phosphorylation of presenilin 1, 2 and tau [58], but it is very unclear whether this has anything to do with NMDA receptor blockade due to the very high dose used (50 mg/kg).
Positive_regulation (caused) of Phosphorylation (phosphorylation) of GSK-3 associated with nmda receptor
13) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.54 Pain Relevance 0.20

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