INT261870

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.50
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Pkd2l1) endoplasmic reticulum (Pkd2l1) plasma membrane (Pkd2l1)
Anatomy Link Frequency
glial cell 1
taste receptor cells 1
receptor cells 1
neural 1
Pkd2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 32 92.68 High High
Neuropeptide 1 89.96 High High
anesthesia 7 88.24 High High
ketamine 7 84.40 Quite High
adenocard 1 81.04 Quite High
Serotonin 6 78.16 Quite High
midbrain 1 63.04 Quite High
Ventral tegmentum 1 60.08 Quite High
member 8 1 55.36 Quite High
Nucleus accumbens 1 44.08 Quite Low
Disease Link Frequency Relevance Heat
Cyst 2 95.56 Very High Very High Very High
Hyperplasia 2 94.76 High High
Disease 40 93.04 High High
Autosomal Dominant Polycystic Kidney 4 92.72 High High
Carbuncle 2 88.64 High High
Pressure And Volume Under Development 10 88.08 High High
Fever 2 87.80 High High
Ganglion Cysts 18 77.36 Quite High
Aids-related Complex 1 65.92 Quite High
Targeted Disruption 28 62.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of ghrelin receptor ablation to affect the response to a sour stimulus could potentially be due to a role of ghrelin in controlling cell to cell signaling between TCs and the Type III (‘presynaptic’) cells, which possess the putative sour receptor (PKD2L1).
Gene_expression (possess) of PKD2L1
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.07 Pain Relevance 0.24
Smooth PCL produced no detectable changes in RPC expression of mature retinal neural markers.
Gene_expression (produced) of PCL in neural
2) Confidence 0.25 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
Fig. 3Characterization of RPCs cultured on PCL scaffolds for 7 days. a–h, i–p, q–x Short nanowire, long nanowire, and smooth RPC-seeded PCL scaffolds, respectively. a, i, q CRX did not show expression. b, j, r PKC showed expression only on SNW and LNW. c, k, s While Nestin was expressed on SNW, LNW, and smooth, d, l, t Ki67 and e, m, u 4D2 were only expressed on SNW.
Gene_expression (scaffolds) of PCL
3) Confidence 0.22 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
Briefly, SNW and LNW PCL scaffolds with adherent RPCs were cut into 1.0?
Gene_expression (scaffolds) of PCL
4) Confidence 0.22 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0.14 Pain Relevance 0.13
The most pronounced morphologic changes occurred in RPCs cultured on SNW PCL at days 3 and 7 (Fig. 2a and b).
Gene_expression (cultured) of PCL
5) Confidence 0.22 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0.05
The PCL solution was cast onto a nanoporous anodized aluminum oxide template using a spin coater (Specialty Coating Systems, Indianapolis, IN, USA).
Gene_expression (solution) of PCL
6) Confidence 0.22 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0.06 Pain Relevance 0
The glial cell marker (f, n, v) GFAP was expressed on SNW and smooth PCL. g, o, w Recoverin was only expressed on LNW and SNW. h, p, x nf-200 showed expression on each scaffold.
Gene_expression (expressed) of PCL in glial cell
7) Confidence 0.22 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
PCL is template-synthesized to form short (?
Gene_expression (synthesized) of PCL
8) Confidence 0.19 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
On the other hand, it was shown that PKD2L1 in the tongue is expressed in a subset of taste receptor cells distinct from those responsible for sweet, bitter and umami taste [60].
Gene_expression (expressed) of PKD2L1 in taste receptor cells
9) Confidence 0.18 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0.64 Pain Relevance 0
Furthermore, mice lacking PKD2L1 expressing receptor cells are completely devoid of taste responses to sour stimuli [39].
Gene_expression (expressing) of PKD2L1 in receptor cells
10) Confidence 0.18 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0.59 Pain Relevance 0

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