INT261879

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.59
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (PKD2) endoplasmic reticulum (PKD2) plasma membrane (PKD2)
cilium (PKD2) transmembrane transport (PKD2) cytoplasm (PKD2)
PKD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 37 100.00 Very High Very High Very High
fibrosis 2 43.64 Quite Low
qutenza 96 6.16 Low Low
imagery 31 5.00 Very Low Very Low Very Low
Pain 30 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
Inflammation 22 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
cannabis 12 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autosomal Dominant Polycystic Kidney 115 93.68 High High
Fever 2 83.68 Quite High
Pressure And Volume Under Development 11 83.12 Quite High
Carbuncle 2 82.32 Quite High
Congenital Anomalies 6 74.16 Quite High
Disease 43 73.36 Quite High
Apoptosis 2 71.20 Quite High
Hyperplasia 2 71.12 Quite High
Cyst 27 68.08 Quite High
Death 3 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association of TRPP1 and TRPP2 suppresses the ability of TRPP1 to activate G proteins as well as the constitutive channel activity of TRPP2 [81].
TRPP2 Binding (association) of
1) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0.60 Pain Relevance 0
A recent report shows that triptolide, the active diterpene in the traditional Chinese medicine Lei Gong Ten, binds to TRPP2 directly and induces Ca2+ release by a TRPP2-dependent mechanism.
TRPP2 Binding (binds) of
2) Confidence 0.13 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0.64 Pain Relevance 0
Polycystin-2 is a member of the calcium-permeable subfamily of transient receptor potential channels and forms a complex with polycystin-1 [17].
Polycystin-2 Binding (complex) of associated with trp channel
3) Confidence 0.07 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.34 Pain Relevance 0.05

General Comments

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