INT261886

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
neuronal 1
Htt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 9 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
projection neuron 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 69 100.00 Very High Very High Very High
Aging 41 98.50 Very High Very High Very High
Stress 5 98.00 Very High Very High Very High
Parkinson's Disease 2 97.58 Very High Very High Very High
Targeted Disruption 8 93.20 High High
Toxicity 14 55.60 Quite High
Drug Induced Neurotoxicity 2 50.00 Quite Low
Disease Progression 2 22.12 Low Low
Infection 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because BDNF levels are reduced in the brains of HD patients and HD mouse models, we sought to investigate whether Htt might be involved in the transport of BDNF mRNA through neuronal RNA granules.
Spec (might) Regulation (involved) of Htt in neuronal associated with disease
1) Confidence 0.43 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.20 Pain Relevance 0
Thus, mitochondrial dysfunction and oxidative stress linked to “normal” aging may, along with mutant Htt-induced mitochondrial defects, synergistically modulate HD pathogenesis [9], [50].
Regulation (modulate) of HD associated with stress, parkinson's disease, aging and disease
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 1.87 Pain Relevance 0

General Comments

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