INT261891

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
neurons 2
Htt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
projection neuron 2 85.20 High High
imagery 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 104 100.00 Very High Very High Very High
Toxicity 26 90.40 High High
Targeted Disruption 16 79.68 Quite High
Infection 20 73.12 Quite High
Aging 82 68.24 Quite High
Drug Induced Neurotoxicity 4 50.00 Quite Low
Neurodegenerative Disease 12 45.60 Quite Low
Stress 10 5.00 Very Low Very Low Very Low
Parkinson's Disease 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with this, neuroprotective strategies not directly targeting transcription (e.g. chaperones and calcineurin) block the loss of DARPP32 produced by mutant Htt in our rat model [12], [13], [61].
Negative_regulation (loss) of Gene_expression (produced) of mutant Htt
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.21 Pain Relevance 0
The reduction of DARPP-32 immunoreactivity in our HD rat model probably results from a loss of expression of DARPP-32 in dysfunctional neurons and/or an actual loss of striatal neurons.
Negative_regulation (reduction) of Gene_expression (model) of HD in neurons associated with disease
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.92 Pain Relevance 0.04

General Comments

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