INT26191

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Context Info
Confidence 0.44
First Reported 1989
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 1.90
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
platelets 2
nose 2
internal 1
SK-N-SH 1
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 264 99.82 Very High Very High Very High
antagonist 38 99.76 Very High Very High Very High
bradykinin 98 99.34 Very High Very High Very High
Enkephalin 8 98.80 Very High Very High Very High
Clonidine 2 97.54 Very High Very High Very High
Kinase C 47 95.56 Very High Very High Very High
aspirin 83 95.52 Very High Very High Very High
5HT 141 86.32 High High
nociceptor 21 80.88 Quite High
Serotonin 14 80.28 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 89 98.56 Very High Very High Very High
Glioma 13 88.72 High High
Congenital Anomalies 7 88.08 High High
Helminth Infection 98 81.76 Quite High
Pain 18 80.08 Quite High
Convulsion 1 79.76 Quite High
Depression 2 79.24 Quite High
Leiomyosarcoma 1 78.24 Quite High
Pathologic Processes 2 77.72 Quite High
Neuroblastoma 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with a role of IP3 and calmodulin in the effects of these drugs.
Positive_regulation (role) of IP3
1) Confidence 0.44 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7774682 Disease Relevance 0 Pain Relevance 0.26
On the other hand, additive effects were observed in both [Ca2+]i rise and IP3 generation when leu-EK was simultaneously added with bradykinin.
Positive_regulation (generation) of IP3 associated with bradykinin
2) Confidence 0.24 Published 1995 Journal Chin J Physiol Section Abstract Doc Link 8697901 Disease Relevance 0.07 Pain Relevance 0.48
Carbachol stimulated significantly higher increase in inositol 1,4,5-trisphosphate (IP3) generation than did leucine-enkephalin (leu-EK) and bradykinin in SK-N-SH cells.
Positive_regulation (increase) of IP3 in SK-N-SH associated with enkephalin and bradykinin
3) Confidence 0.24 Published 1995 Journal Chin J Physiol Section Abstract Doc Link 8697901 Disease Relevance 0.07 Pain Relevance 0.29
We also show that IP3Rs are required for the response to the volatile compound benzaldehyde.
Positive_regulation (required) of IP3Rs
4) Confidence 0.18 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2729924 Disease Relevance 0.08 Pain Relevance 0.19
IP3 independent activation of IP3Rs by proteins ligands such as CaBP (Ca2+ binding protein), CIB1 (Ca2+ and integrin binding 1, also known as calmyrin) and G-protein ??
Positive_regulation (activation) of IP3Rs
5) Confidence 0.17 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.08 Pain Relevance 0
The ability of the IP3 sponge to disrupt nose touch and the rescue of nose touch defects in plc-3 and egl-8 RNAi animals by an itr-1 gain-of-function allele, both support the conclusion that IP3 is the signalling molecule downstream of PLC and upstream of itr-1 activation.
Positive_regulation (activation) of IP3 in nose
6) Confidence 0.17 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0.04
PLCs catalyse the hydrolysis of PIP2, to produce IP3 (Figure 1) and are therefore good candidates for the source of signal that activates the IP3R.
Positive_regulation (activates) of IP3R
7) Confidence 0.17 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0
Thus nose touch requires a canonical IP3 signalling pathway in ASH.
Positive_regulation (requires) of IP3 in nose
8) Confidence 0.16 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0.04
Although we cannot rule out that the action of PLCs is redundant in this response, this data is compatible with the suggestion that this response does not depend on IP3 (Figure 3I).


Neg (not) Positive_regulation (depend) of IP3
9) Confidence 0.16 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.05 Pain Relevance 0
Clonidine (an alpha-2 agonist), isoproterenol, and NE in the presence of phentolamine or prazosin (an alpha-1 antagonist) failed to increase IP3.
Neg (failed) Positive_regulation (increase) of IP3 associated with antagonist, agonist and clonidine
10) Confidence 0.16 Published 1989 Journal Biol. Reprod. Section Abstract Doc Link 2572279 Disease Relevance 0.08 Pain Relevance 0.36
Thus, high levels of ADP could replace thromboxane as stimulator of IP3 by activation of P2Y1 receptors.
Positive_regulation (stimulator) of IP3
11) Confidence 0.15 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.36 Pain Relevance 0.35
IP3 independent activation of IP3Rs by proteins ligands such as CaBP (Ca2+ binding protein), CIB1 (Ca2+ and integrin binding 1, also known as calmyrin) and G-protein ??
Positive_regulation (activation) of IP3
12) Confidence 0.15 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.08 Pain Relevance 0
E alone did not change significantly the level of IP3 in platelets, nor did it influence the cyclic AMP level.
Neg (not) Positive_regulation (change) of IP3 in platelets
13) Confidence 0.10 Published 1989 Journal Biokhimiia Section Abstract Doc Link 2551395 Disease Relevance 0 Pain Relevance 0.13
In this model, an agonist-induced increase in IP3 stimulates the release of calcium from an IP3-sensitive intracellular calcium storage site into the cytoplasm.
Positive_regulation (increase) of IP3 associated with agonist
14) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.08
These findings strictly parallel those by Delorme et al (2004) showing a disturbance in the second messenger pathway coupled to 5HT2 receptors with enhanced IP3 concentrations in the platelets of OCD patients.
Positive_regulation (enhanced) of IP3 in platelets associated with anxiety disorder
15) Confidence 0.06 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.49 Pain Relevance 0.39
The net effect of increased IP3 and DAG levels is to increase intracellular Ca2+ through release from internal stores and influx from membrane-bound channels [3], and in ASM to activate the cell's contractile machinery through both Ca2+ and protein kinase C (PKC) -dependent mechanisms [30-33] (see Fig. 1 Legend for details).
Positive_regulation (increased) of IP3 in internal associated with kinase c
16) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.13
and increases levels of inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG), leading to elevations in intracellular calcium concentration and the activation of protein kinase C (PKC).
Positive_regulation (increases) of IP3 associated with kinase c
17) Confidence 0.04 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.33 Pain Relevance 0.19
activation leading to increases in IP3 generation and mobilization of [Ca2+]i.
Positive_regulation (increases) of IP3
18) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
328 cells with U46619 also yielded efficient increases in IP3 generation (Figs. 2G and H, respectively).
Positive_regulation (increases) of IP3
19) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.07 Pain Relevance 0.13
Exact mechanisms linking PIP3 formation to Ca2+ signals are not yet known, but PIP3 may activate a PLC isoform triggering InsP3 production [118].
Positive_regulation (triggering) of InsP3
20) Confidence 0.03 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

General Comments

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