INT261979

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 6.95
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDCD1) plasma membrane (PDCD1) signal transducer activity (PDCD1)
Anatomy Link Frequency
B cells 1
myeloid cells 1
Cytotoxic T lymphocyte 1
T cells 1
PDCD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 88.24 High High
rheumatoid arthritis 7 84.48 Quite High
Central nervous system 3 59.44 Quite High
Multiple sclerosis 3 57.60 Quite High
spinal inflammation 6 55.20 Quite High
Serotonin 7 49.20 Quite Low
sNRI 4 45.44 Quite Low
depression 2 41.68 Quite Low
Lasting pain 2 18.08 Low Low
antidepressant 1 16.08 Low Low
Disease Link Frequency Relevance Heat
Disease 60 99.80 Very High Very High Very High
Death 3 96.00 Very High Very High Very High
Apoptosis 13 95.56 Very High Very High Very High
Syndrome 66 91.12 High High
Rheumatoid Arthritis 10 84.48 Quite High
Diabetes Mellitus 8 83.48 Quite High
Autoimmune Disease 16 82.64 Quite High
Genetic Predisposition To Disease 6 69.60 Quite High
Systemic Lupus Erythematosus 6 65.92 Quite High
Alopecia 12 58.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the genes that was identified as an intermediate between PDCD1 and GD is Cytotoxic T lymphocyte-associated antigen 4 (CTLA4) (Figure 5a).
Positive_regulation (intermediate) of PDCD1 in Cytotoxic T lymphocyte associated with disease
1) Confidence 0.49 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 1.46 Pain Relevance 0.04
PD-1 contains an immunoreceptor tyrosine-based inhibiting motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) [7] and is transcriptionally induced in activated T cells, B cells, and myeloid cells [8,9].
Positive_regulation (induced) of PD-1 in myeloid cells
2) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 1.83 Pain Relevance 0.19
PD-1 contains an immunoreceptor tyrosine-based inhibiting motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) [7] and is transcriptionally induced in activated T cells, B cells, and myeloid cells [8,9].
Positive_regulation (induced) of PD-1 in T cells
3) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 1.83 Pain Relevance 0.19
PD-1 contains an immunoreceptor tyrosine-based inhibiting motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) [7] and is transcriptionally induced in activated T cells, B cells, and myeloid cells [8,9].
Positive_regulation (induced) of PD-1 in B cells
4) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 1.83 Pain Relevance 0.19

General Comments

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