INT262

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Context Info
Confidence 0.61
First Reported 1977
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 3.03
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
skin 1
dura mater 1
cavity 1
trigeminal nerve 1
urine 1
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 2 100.00 Very High Very High Very High
cINOD 32 99.92 Very High Very High Very High
aspirin 14 99.76 Very High Very High Very High
Calcitonin gene-related peptide 4 99.34 Very High Very High Very High
lidocaine 7 98.40 Very High Very High Very High
antagonist 36 98.00 Very High Very High Very High
fifth nerve 4 97.54 Very High Very High Very High
Dismenorea 1 93.68 High High
substance P 4 93.28 High High
diclofenac 3 92.48 High High
Disease Link Frequency Relevance Heat
Glioma 4 97.60 Very High Very High Very High
INFLAMMATION 33 96.36 Very High Very High Very High
Anaphylaxis 1 91.72 High High
Acidosis 4 91.64 High High
Cv Unclassified Under Development 5 89.76 High High
Headache 4 89.04 High High
Ganglion Cysts 44 87.24 High High
Depression 1 77.24 Quite High
Pain 6 36.16 Quite Low
Nervous System Injury 12 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: EMLA cream induced a significant inhibition of TXB2 (P<0.05) and 6-Keto-PGF1alpha (P<0.01) but not of PGE release from burned skin as compared to saline treatment.
Localization (release) of PGE in skin
1) Confidence 0.61 Published 1999 Journal Acta Anaesthesiol Scand Section Body Doc Link 10408815 Disease Relevance 0 Pain Relevance 0
Release of PGE and F from inflamed synovial membrane was increased.
Localization (Release) of PGE
2) Confidence 0.60 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 544394 Disease Relevance 0.25 Pain Relevance 0.28
Hydrocortisone suppressed release of PGE and F from inflamed synovial membrane in vivo, and did not influence PG release in vitro.
Localization (release) of PGE
3) Confidence 0.60 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 544394 Disease Relevance 0.24 Pain Relevance 0.28
Aspirin suppressed PGE and F release from non-inflamed and inflamed synovial membrane in vivo and in vitro, but suppression of PGF release was more intense.
Localization (release) of PGE associated with aspirin
4) Confidence 0.60 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 544394 Disease Relevance 0.24 Pain Relevance 0.28
Release of PGE and F fron non-inflamed synovial membrane was not influenced by hydrocortisone in vivo and in vitro.
Localization (Release) of PGE
5) Confidence 0.60 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 544394 Disease Relevance 0.23 Pain Relevance 0.28
Moreover, we compared the release of PGE(2) and glutamate after i.t. injections of levobupivacaine or lidocaine.
Localization (release) of PGE associated with glutamate and lidocaine
6) Confidence 0.54 Published 2009 Journal Br J Anaesth Section Abstract Doc Link 19252201 Disease Relevance 0 Pain Relevance 0.62
In the spayed group at 60 min of functioning (i.e. when the contractile impairment was significantly smaller than at a later time) the release of PGE was greater than at 360 min.
Localization (release) of PGE
7) Confidence 0.45 Published 1979 Journal Prostaglandins Section Abstract Doc Link 573914 Disease Relevance 0.08 Pain Relevance 0.13
The PGE-like release had a threshold at about 2 microgram/ml of tryptamine or 5-HT and did not increase with increasing doses (up to 10 microgram/ml); this release was abolished by methysergide, BC 105 and BW 501c67 but not by morphine.
Localization (release) of PGE-like associated with morphine
8) Confidence 0.35 Published 1977 Journal Eur. J. Pharmacol. Section Abstract Doc Link 21802 Disease Relevance 0.09 Pain Relevance 0.27
Given that EP3A and EP3B mRNA are not found in DRGs [39] and EP3C (i.e., EP3?)
Localization (i.e.) of EP3
9) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.32 Pain Relevance 0.35
Given that EP3A and EP3B mRNA are not found in DRGs [39] and EP3C (i.e., EP3?)
Localization (i.e.) of EP3C
10) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.32 Pain Relevance 0.35
Inflamed synovial tissue, as induced 6 hours after carrageenin injection into the knee joint cavity of rats was used to examine the inhibitory action of NSAID on PGE release from the tissue.
Spec (examine) Localization (release) of PGE in cavity associated with cinod
11) Confidence 0.26 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6781993 Disease Relevance 0.08 Pain Relevance 0.76
The excretion of urinary PGE was significantly decreased by administration of NSAID.
Localization (excretion) of PGE associated with cinod
12) Confidence 0.26 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6781993 Disease Relevance 0.07 Pain Relevance 0.77
Effects of NSAID on the excretion of PGE and PG main urinary metabolite (PGMUM) in rat urine were determined.
Localization (excretion) of PGE in urine associated with cinod
13) Confidence 0.26 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6781993 Disease Relevance 0.07 Pain Relevance 0.77
ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater.
Localization (release) of PGE in dura mater
14) Confidence 0.07 Published 2002 Journal Pain Section Title Doc Link 12044622 Disease Relevance 0.27 Pain Relevance 0.22
The dura was chemically stimulated and the amounts of immunoreactive calcitonin gene-related peptide (iCGRP) and prostaglandin E(2) (PGE(2)) released into incubation fluid were measured using enzyme immunoassays.
Localization (released) of PGE associated with calcitonin gene-related peptide
15) Confidence 0.07 Published 2002 Journal Pain Section Abstract Doc Link 12044622 Disease Relevance 0.25 Pain Relevance 0.22
The proton-reduction of PGE(2) release was overcome by adding ATP (10(-3)M).
Localization (release) of PGE
16) Confidence 0.07 Published 2002 Journal Pain Section Abstract Doc Link 12044622 Disease Relevance 0.18 Pain Relevance 0.29
The present results provide evidence that ATP has poor, if at all, direct excitatory effects on CGRP-containing trigeminal nerve endings in the isolated dura and its facilitatory action seems to depend on G-protein coupled P2Y receptors and secondary PGE(2) release.
Localization (release) of PGE in trigeminal nerve associated with fifth nerve
17) Confidence 0.07 Published 2002 Journal Pain Section Abstract Doc Link 12044622 Disease Relevance 0 Pain Relevance 0.23
An 18-h treatment with gamma-mangostin potently inhibited spontaneous PGE(2) release in a concentration-dependent manner with the IC(50) value of approximately 2 microM, without affecting the cell viability even at 30 microM.
Localization (release) of PGE
18) Confidence 0.03 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.17 Pain Relevance 0
We investigated the effect of gamma-mangostin purified from the fruit hull of the medicinal plant Garcinia mangostana on spontaneous prostaglandin E(2) (PGE(2)) genase release and inducible cyclooxy-2 (COX-2) gene expression in C6 rat glioma cells.
Localization (release) of PGE associated with glioma
19) Confidence 0.03 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.17 Pain Relevance 0

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