INT262003

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1B1) endoplasmic reticulum (CYP1B1)
CYP1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 12 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 492 99.00 Very High Very High Very High
Disease 70 92.48 High High
Brain Stem Infarctions 4 66.88 Quite High
Retinoblastoma 2 65.04 Quite High
Corneal Edema 6 57.44 Quite High
Hydrophthalmos 6 56.80 Quite High
Ocular Hypertension 60 54.32 Quite High
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Blindness 6 5.00 Very Low Very Low Very Low
Photophobia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Haplotype analysis, however, suggested linkage to the CYP1B1 locus, GLC3A (Figure 1B).
CYP1B1 Spec (suggested) Binding (linkage) of
1) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2709423 Disease Relevance 0.65 Pain Relevance 0
Haplotype analysis, however, suggested linkage to the CYP1B1 locus, GLC3A (Figure 1B).
GLC3A Spec (suggested) Binding (linkage) of
2) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2709423 Disease Relevance 0.66 Pain Relevance 0
CYP1B1 enzymatic assay
CYP1B1 Binding (assay) of
3) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0 Pain Relevance 0
Incomplete penetrance, particularly although not exclusively associated with hypomorphic CYP1B1 alleles, indicates that PCG is not a simple recessive trait and underscores its multifactorial character at least in a subset of patients.
CYP1B1 Binding (associated) of associated with glaucoma
4) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645906 Disease Relevance 0.55 Pain Relevance 0
In some studies, CYP1B1 mutations have been reported to be associated with primary open-angle glaucoma (POAG, OMIMĀ 137760) [13-17].
CYP1B1 Binding (associated) of associated with glaucoma
5) Confidence 0.37 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901188 Disease Relevance 1.21 Pain Relevance 0
CYP1B1 haplotype background
CYP1B1 Binding (background) of
6) Confidence 0.37 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901188 Disease Relevance 0.26 Pain Relevance 0

General Comments

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