INT262043

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr0b2) DNA binding (Nr0b2) protein complex (Nr0b2)
transcription factor binding (Nr0b2) cytoplasm (Nr0b2)
Anatomy Link Frequency
Bile 2
Nr0b2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 117 99.30 Very High Very High Very High
agonist 50 91.76 High High
Inflammation 54 71.08 Quite High
fibrosis 1 49.04 Quite Low
antagonist 21 5.00 Very Low Very Low Very Low
Crohn's disease 18 5.00 Very Low Very Low Very Low
antidepressant 9 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Taxol 6 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 1 91.48 High High
Hypoxia 2 86.12 High High
Heart Rate Under Development 1 84.28 Quite High
Nash(non-alcoholic Steatohepatitis) 2 81.96 Quite High
Alcoholic Fatty Liver 1 76.20 Quite High
INFLAMMATION 41 71.08 Quite High
Targeted Disruption 57 69.12 Quite High
Hyperinsulinism 3 53.48 Quite High
Metabolic Syndrome 13 50.88 Quite High
Insulin Resistance 18 49.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SXR can also directly regulate SHP expression [Frank et al., 2005] and FXR regulates CYP3A4 transcription through two functional FXR response elements in the promoter of CYP3A4 [Goodwin et al., 1999].
Gene_expression (expression) of SHP
1) Confidence 0.23 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.07 Pain Relevance 0.23
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
Gene_expression (expression) of SHP in Bile associated with bile
2) Confidence 0.23 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.13 Pain Relevance 0.23
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
Gene_expression (expression) of small heterodimer partner in Bile associated with bile
3) Confidence 0.23 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.13 Pain Relevance 0.23
In this model, fenofibrate induced AMPK-mediated SHP gene expression, but reduced plasminogen activator inhibitor-1 (PAI-1) mRNA and protein expression [5].
Gene_expression (expression) of SHP gene
4) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.67 Pain Relevance 0.12

General Comments

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