INT262048

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27a1) oxidoreductase activity (Cyp27a1)
Anatomy Link Frequency
intestinal cells 2
Cyp27a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 96.72 Very High Very High Very High
Bile 39 55.28 Quite High
antagonist 7 48.88 Quite Low
Inflammation 17 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 8 98.84 Very High Very High Very High
Cardiovascular Disease 1 87.16 High High
Hyperlipidemia 3 84.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 81.52 Quite High
Disorder Of Lipid Metabolism 4 64.40 Quite High
Targeted Disruption 17 60.24 Quite High
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cafestol can induce intestinal CYP27A1 and ABCA1 expression and promotes cholesterol efflux to the liver via SXR activation, which is consistent with SXR effects in intestinal cells [Li et al., 2007].
Positive_regulation (induce) of Gene_expression (expression) of CYP27A1 in intestinal cells
1) Confidence 0.18 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.68 Pain Relevance 0.08

General Comments

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