INT262054

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 100.00 Very High Very High Very High
Bile 78 55.20 Quite High
agonist 18 45.04 Quite Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 8 99.72 Very High Very High Very High
Repression 6 98.20 Very High Very High Very High
Cancer 36 95.92 Very High Very High Very High
Disease 20 95.48 Very High Very High Very High
Inflammatory Bowel Disease 64 91.12 High High
Targeted Disruption 34 88.32 High High
Celiac Disease 2 69.68 Quite High
Infection 4 40.12 Quite Low
Colitis 2 29.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, studies have shown that SXR activation can affect serum HDL-C and ApoA-I levels [Bachmann et al., 2004; Masson et al., 2005].
Regulation (affect) of Gene_expression (activation) of SXR associated with disorder of lipid metabolism
1) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.24 Pain Relevance 0.03
Zhou et al. observed increased pro-inflammatory gene expression in SXR KO mice, which is likely due to the loss of repression of NF-?
Regulation (pro) of Gene_expression (expression) of SXR associated with inflammation and repression
2) Confidence 0.37 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.21 Pain Relevance 0.33

General Comments

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