INT262060

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.84
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) cell morphogenesis (Vdr) nucleus (Vdr)
DNA binding (Vdr)
Vdr (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 22 96.68 Very High Very High Very High
Bile 96 95.92 Very High Very High Very High
agonist 44 67.64 Quite High
dexamethasone 7 53.88 Quite High
fibrosis 2 48.00 Quite Low
antiepileptic Drug 2 41.52 Quite Low
carbamazepine 2 36.72 Quite Low
Inflammation 43 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Multiple sclerosis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporotic Fractures 4 100.00 Very High Very High Very High
Targeted Disruption 42 99.96 Very High Very High Very High
Aging 2 98.80 Very High Very High Very High
Multiple Sclerosis 50 98.20 Very High Very High Very High
Hypocalcemia 3 97.80 Very High Very High Very High
Hypercalcemia 12 97.24 Very High Very High Very High
Hypophosphatemia 3 97.24 Very High Very High Very High
Central Nervous System Disease 21 96.68 Very High Very High Very High
Stress Fractures 53 93.48 High High
Congenital Anomalies 2 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest the possibility that VDR activation modulates CCR6 expression and leads to a functional hypo-responsiveness to CCL20.
Positive_regulation (activation) of VDR
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.48 Pain Relevance 0.12
Individuals with the C allele have a shorter VDR than those with the T allele, and there is in vitro evidence for enhanced activity of VDR as a transcription factor.
Positive_regulation (enhanced) of VDR
2) Confidence 0.50 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.51 Pain Relevance 0
These features were more prominent in the VDR-null mouse after weaning and with aging, suggesting a role for the VDR in skeletal development and maturation.
Positive_regulation (prominent) of VDR-null associated with aging
3) Confidence 0.50 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.56 Pain Relevance 0
VDR genotypes increase the risk for low BMD and osteoporotic fractures [16,38] and VDR knock-out mice develop a low bone mass phenotype with hypocalcemia, hypophosphatemia, and elevated 1,25(OH)2D3 levels [39].
Positive_regulation (increase) of VDR associated with targeted disruption, hypocalcemia, hypophosphatemia and osteoporotic fractures
4) Confidence 0.50 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.97 Pain Relevance 0
Its active metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), elicits most of its effects through activation of the vitamin D receptor (VDR) [Jones et al., 1998; Omdahl and May, 2004].
Positive_regulation (activation) of VDR
5) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.20
Its active metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), elicits most of its effects through activation of the vitamin D receptor (VDR) [Jones et al., 1998; Omdahl and May, 2004].
Positive_regulation (activation) of vitamin D receptor
6) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.20
The vitamin D receptor (VDR, NR1I1) is activated not only by 1?
Positive_regulation (activated) of vitamin D receptor
7) Confidence 0.08 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.07
The vitamin D receptor (VDR, NR1I1) is activated not only by 1?
Positive_regulation (activated) of NR1I1
8) Confidence 0.08 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.07

General Comments

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