INT262063

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.76
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) cell morphogenesis (Vdr) nucleus (Vdr)
DNA binding (Vdr)
Anatomy Link Frequency
CAR 1
kidney 1
Vdr (Mus musculus)
Pain Link Frequency Relevance Heat
antiepileptic Drug 2 78.16 Quite High
carbamazepine 2 73.36 Quite High
Bile 78 70.08 Quite High
Inflammation 34 67.52 Quite High
agonist 18 48.48 Quite Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress Fractures 159 93.44 High High
Osteoporosis 23 89.24 High High
Disease 26 68.80 Quite High
Infection 4 68.04 Quite High
INFLAMMATION 24 67.52 Quite High
Metabolic Bone Disease 2 67.52 Quite High
Inflammatory Bowel Disease 64 66.64 Quite High
Rickets 16 65.52 Quite High
Obesity 81 65.44 Quite High
Toxicity 8 64.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of the VDR gene, the FokI (rs10735810) and the TaqI-BsmI (rs731236 & rs1544410) SNPs were located in two different haplotype blocks.
Localization (located) of VDR
1) Confidence 0.75 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.54 Pain Relevance 0
Genotyping of the VDR, CTR, and IL-6 variations was performed as described previously [16,18,21,24,25].
Localization (variations) of VDR
2) Confidence 0.75 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.07 Pain Relevance 0
In our study, the CTR allele C together with a VDR C-A haplotype appeared to protect subjects from fractures.
Localization (haplotype) of VDR
3) Confidence 0.75 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.36 Pain Relevance 0
B and other nuclear receptors, since RXR is a common partner for many nuclear receptors including CAR, VDR, RAR, TR, LXR and PPARs [Xie and Tian, 2006].
Localization (receptors) of VDR in CAR
4) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.50 Pain Relevance 0.13
CYP24 is directly regulated by VDR and it is expressed mainly in the kidney where VDR is also abundant.
Localization (abundant) of VDR in kidney
5) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.30 Pain Relevance 0.21

General Comments

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