INT262067

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Context Info
Confidence 0.68
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc)
extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc) plasma membrane (Tfrc)
Anatomy Link Frequency
CAR 1
vesicle 1
Tfrc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 69.36 Quite High
Central nervous system 22 32.88 Quite Low
agonist 9 15.52 Low Low
Bile 39 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 1 70.72 Quite High
INFLAMMATION 15 69.36 Quite High
Infection 2 68.04 Quite High
Inflammatory Bowel Disease 32 67.36 Quite High
Disease 11 56.80 Quite High
Cancer 18 55.76 Quite High
Hypoxia 2 53.04 Quite High
Repression 3 40.40 Quite Low
Necrosis 1 39.52 Quite Low
Targeted Disruption 17 32.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon binding, the Tf-TfR complex internalizes to a vesicle, iron is released from Tf, reduced to the transportable ferrous form (Fe2+) by a vesicular reductase, Steap3 (Ohgami et al. 2006) and transported across the endosomal membrane into cytosol by DMT1 found in the vesicular membrane.
Localization (released) of TfR in vesicle
1) Confidence 0.68 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0.19 Pain Relevance 0.03
B and other nuclear receptors, since RXR is a common partner for many nuclear receptors including CAR, VDR, RAR, TR, LXR and PPARs [Xie and Tian, 2006].
Localization (receptors) of TR in CAR
2) Confidence 0.10 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.50 Pain Relevance 0.13

General Comments

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