INT262068

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.35
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 36 56.04 Quite High
Bile 156 5.00 Very Low Very Low Very Low
Inflammation 68 5.00 Very Low Very Low Very Low
antagonist 28 5.00 Very Low Very Low Very Low
Crohn's disease 24 5.00 Very Low Very Low Very Low
antidepressant 12 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Taxol 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
carbamazepine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 4 89.56 High High
Breast Cancer 32 65.60 Quite High
Inflammatory Bowel Disease 128 5.00 Very Low Very Low Very Low
Cancer 72 5.00 Very Low Very Low Very Low
Targeted Disruption 68 5.00 Very Low Very Low Very Low
INFLAMMATION 48 5.00 Very Low Very Low Very Low
Disease 40 5.00 Very Low Very Low Very Low
Rickets 32 5.00 Very Low Very Low Very Low
Osteoporosis 28 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They also showed that nuclear localization signal (NLS), xenobiotic response signal (XRS) and AF2 domain are all required for nuclear translocation of SXR.
Localization (translocation) of SXR
1) Confidence 0.75 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0
SXR and species-specific xenobiotic metabolism
Localization (metabolism) of SXR
2) Confidence 0.70 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.07 Pain Relevance 0
The subcellular localization of SXR is currently controversial.
Localization (localization) of SXR
3) Confidence 0.70 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.06 Pain Relevance 0.03
Based on microinjection studies and transient transfection assays, Kawana et al. reported that amino acids 66-92 are important for nuclear import of SXR [Kawana et al., 2003].
Localization (import) of SXR
4) Confidence 0.58 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.09 Pain Relevance 0

General Comments

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