INT262077

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.34
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) lipid metabolic process (Insig1)
Insig1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 39 99.50 Very High Very High Very High
Bile 78 39.44 Quite Low
Inflammation 34 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 18 95.08 Very High Very High Very High
Targeted Disruption 43 89.00 High High
Disease 21 54.88 Quite High
Diabetes Mellitus 24 50.40 Quite High
Disorder Of Lipid Metabolism 8 46.64 Quite Low
Neurodegenerative Disease 2 46.16 Quite Low
Van Bogaert's Disease 2 45.00 Quite Low
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Cancer 36 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrated that BLI allows the detection of activation of insulin gene in vivo via reporter luciferase expression in a timely and semi-quantitative manner.
Positive_regulation (activation) of insulin gene associated with imagery
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.29 Pain Relevance 0.21
SXR activation is also associated with induction of Insig-1, a protein with anti-lipogenic properties, and with reduced protein levels of the active form or SREBP-1 [Roth et al., 2008].
Positive_regulation (induction) of Insig-1
2) Confidence 0.15 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.05 Pain Relevance 0
A functional SXR binding site was found in the Insig-1 promoter and it was suggested that Insig-1 induction by SXR could lead to decreased levels of active SREBP-1 and reduced triglyceride synthesis.
Positive_regulation (induction) of Insig-1
3) Confidence 0.10 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0

General Comments

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