INT262079

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.71
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) cell morphogenesis (Vdr) nucleus (Vdr)
DNA binding (Vdr)
Vdr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 80.08 Quite High
Bile 39 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress Fractures 53 90.48 High High
Obesity 27 84.44 Quite High
Targeted Disruption 18 84.24 Quite High
Nicotine Addiction 3 70.28 Quite High
Rickets 8 58.32 Quite High
Body Weight 9 52.08 Quite High
Genetic Predisposition To Disease 1 50.00 Quite Low
Disease 12 22.64 Low Low
Osteoporotic Fractures 2 12.68 Low Low
Metabolic Bone Disease 1 5.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A linkage disequilibrium plot for the VDR, COL1A1, COL1A2, and LRP5 SNPs is presented in Figures 1A-D.
Negative_regulation (presented) of VDR
1) Confidence 0.42 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.56 Pain Relevance 0
Instead, SXR was shown to be able to crosstalk with VDR to inhibit VDR-mediated CYP24 promoter activity.
Negative_regulation (inhibit) of VDR-mediated
2) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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