INT262087

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.64
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2d9) endoplasmic reticulum (Cyp2d9)
Anatomy Link Frequency
liver 1
intestine 1
Cyp2d9 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 96.32 Very High Very High Very High
agonist 27 82.48 Quite High
Inflammatory stimuli 3 68.96 Quite High
anticonvulsant 3 53.60 Quite High
Bile 117 5.00 Very Low Very Low Very Low
antagonist 21 5.00 Very Low Very Low Very Low
Crohn's disease 18 5.00 Very Low Very Low Very Low
antidepressant 9 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Taxol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 24 97.48 Very High Very High Very High
Inflammatory Bowel Disease 96 96.32 Very High Very High Very High
INFLAMMATION 36 90.32 High High
Infection 6 88.96 High High
Targeted Disruption 51 80.44 Quite High
Cancer 54 5.00 Very Low Very Low Very Low
Disease 30 5.00 Very Low Very Low Very Low
Breast Cancer 24 5.00 Very Low Very Low Very Low
Osteoporosis 21 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It upregulates CYP3A4 expression, while repressing CYP24 and CYP2D25 expression in the liver and intestine.


Gene_expression (expression) of CYP2D25 in intestine
1) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.68 Pain Relevance 0.18
Interestingly, phenobarbital-activated SXR can also inhibit expression of CYP2D25 at the transcriptional level [Hosseinpour et al., 2007].
Gene_expression (expression) of CYP2D25
2) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.28 Pain Relevance 0.07
It upregulates CYP3A4 expression, while repressing CYP24 and CYP2D25 expression in the liver and intestine.


Gene_expression (expression) of CYP2D25 in liver
3) Confidence 0.00 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.68 Pain Relevance 0.18

General Comments

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