INT262094

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.52
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Anatomy Link Frequency
CAR 2
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 92 86.72 High High
agonist 18 48.12 Quite Low
Crohn's disease 13 17.72 Low Low
Inflammation 35 15.20 Low Low
antagonist 14 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 36 99.84 Very High Very High Very High
Breast Cancer 16 85.92 High High
Apoptosis 10 85.04 High High
Disorder Of Lipid Metabolism 8 58.80 Quite High
Targeted Disruption 34 35.92 Quite Low
Neurodegenerative Disease 2 30.92 Quite Low
Van Bogaert's Disease 2 29.76 Quite Low
Disease 21 17.72 Low Low
Stress 2 17.28 Low Low
Diabetes Mellitus 7 16.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These two studies showed opposite effects of SXR activation on lipid homeostasis, suggesting that further research will be required to sort out the details.
Regulation (effects) of Positive_regulation (activation) of SXR
1) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.06 Pain Relevance 0
Considering the possible roles of SXR activation in cancer, and the numerous xenobiotic compounds that are SXR activators, the relationship between SXR and endocrine-disrupting chemicals (EDCs) is very interesting.
Spec (possible) Regulation (roles) of Positive_regulation (activation) of SXR associated with cancer
2) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.46 Pain Relevance 0
This report elegantly provided an explanation as to how an activation of xenobiotic metabolism regulators like CAR and PXR induce Insig-1 by CAR and PXR which may explain the negative effects of some drugs on hepatic lipid levels [14].
Regulation (regulators) of Positive_regulation (activation) of PXR in CAR
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.13

General Comments

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