INT262096

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27a1) oxidoreductase activity (Cyp27a1)
Anatomy Link Frequency
intestinal cells 2
bile 1
Cyp27a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 27 96.00 Very High Very High Very High
Bile 117 95.20 Very High Very High Very High
antagonist 21 48.88 Quite Low
Inflammation 51 5.00 Very Low Very Low Very Low
Crohn's disease 18 5.00 Very Low Very Low Very Low
antidepressant 9 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Taxol 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
carbamazepine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 51 98.92 Very High Very High Very High
Neurodegenerative Disease 3 98.56 Very High Very High Very High
Rickets 24 98.12 Very High Very High Very High
Van Bogaert's Disease 3 97.98 Very High Very High Very High
Cardiovascular Disease 3 86.44 High High
Hyperlipidemia 9 83.72 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 80.80 Quite High
Disorder Of Lipid Metabolism 12 64.40 Quite High
Inflammatory Bowel Disease 96 5.00 Very Low Very Low Very Low
Cancer 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cafestol can induce intestinal CYP27A1 and ABCA1 expression and promotes cholesterol efflux to the liver via SXR activation, which is consistent with SXR effects in intestinal cells [Li et al., 2007].
Gene_expression (expression) of CYP27A1 in intestinal cells
1) Confidence 0.30 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.67 Pain Relevance 0.08
In agreement with this finding, it was recently shown that SXR can directly mediate CYP27A1 expression in cultured intestinal cells [Li et al., 2007].
Gene_expression (expression) of CYP27A1 in intestinal cells
2) Confidence 0.30 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.24 Pain Relevance 0.07
Interestingly, the sterol intermediates of bile acid synthesis are more potent activators of mouse SXR than human SXR, which may explain the development of cerebrotendinous xanthomatosis (a neurodegenerative disease caused by deposition of cholesterol in various tissues) in humans with CYP27A1 deficiency, but not in corresponding knockout mice.
Gene_expression (deficiency) of CYP27A1 in bile associated with targeted disruption, bile, van bogaert's disease and neurodegenerative disease
3) Confidence 0.26 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.30 Pain Relevance 0.18

General Comments

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