INT262100

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.31
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ncor2) DNA binding (Ncor2)
Anatomy Link Frequency
intestinal cells 1
Ncor2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 119 99.20 Very High Very High Very High
cytokine 27 52.40 Quite High
Inflammatory response 19 47.92 Quite Low
cINOD 2 29.36 Quite Low
antidepressant 3 14.28 Low Low
Bile 42 5.00 Very Low Very Low Very Low
agonist 36 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 136 99.20 Very High Very High Very High
Targeted Disruption 51 60.24 Quite High
Cancer 51 50.00 Quite Low
Hypolipidemia 2 50.00 Quite Low
Obesity 28 49.92 Quite Low
Repression 12 17.08 Low Low
Apoptosis 16 14.88 Low Low
Sleep Disorders 1 6.44 Low Low
Affective Disorder 1 5.60 Low Low
Inflammatory Bowel Disease 41 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous deletion of NCoR or SMRT in mice is embryonic lethal, indicating that they cannot fully compensate for each other during development [Ghisletti et al., 2009; Jepsen et al., 2008; Jepsen et al., 2000].
Gene_expression (deletion) of NCoR
1) Confidence 0.42 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.06 Pain Relevance 0
to the NCoR complexes on the promoter of inflammatory genes, including iNOS, in the presence of PPAR-?
Gene_expression (complexes) of NCoR associated with inflammation
2) Confidence 0.38 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.19 Pain Relevance 0.12
Homozygous deletion of NCoR or SMRT in mice is embryonic lethal, indicating that they cannot fully compensate for each other during development [Ghisletti et al., 2009; Jepsen et al., 2008; Jepsen et al., 2000].
Gene_expression (deletion) of SMRT
3) Confidence 0.37 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.06 Pain Relevance 0
Tocotrienols also selectively regulate the SXR target gene CYP3A4 in hepatic and intestinal cell lines, due to different expression levels of nuclear receptor corepressor NCoR in hepatic and intestinal cells [Zhou et al., 2004].
Gene_expression (expression) of NCoR in intestinal cells
4) Confidence 0.06 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0

General Comments

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