INT262101

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hmgcs2)
Hmgcs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 78 5.00 Very Low Very Low Very Low
Inflammation 34 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 93.36 High High
Diabetes Mellitus 6 53.04 Quite High
Insulin Resistance 2 49.76 Quite Low
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Cancer 36 5.00 Very Low Very Low Very Low
Targeted Disruption 34 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Rickets 16 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-oxidation by upregulating transcription of genes including mitochondrial 3-hydroxy-3-methylglutartate-CoA synthase 2 (HMGCS2) and carnitine palmitoyltransferase 1A (CPT1A) during fasting or after prolonged exercise [Wolfrum et al., 2004].
Transcription (transcription) of HMGCS2
1) Confidence 0.32 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.12 Pain Relevance 0
Using wild-type and SXR-/- mice, they showed that treatment with PCN reduced steady-state mRNA levels of HMGCS2 and CPT1A in wild-type, but not in SXR-deficient mice.
Transcription (levels) of HMGCS2
2) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.09 Pain Relevance 0

General Comments

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