INT262102

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h4) DNA binding (Nr1h4)
Anatomy Link Frequency
CAR 1
Nr1h4 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 78 97.52 Very High Very High Very High
agonist 18 91.68 High High
antagonist 14 52.76 Quite High
Inflammation 34 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 34 95.36 Very High Very High Very High
Toxicity 8 87.36 High High
Increased Venous Pressure Under Development 2 78.92 Quite High
Hyperlipidemia 6 78.12 Quite High
Disorder Of Lipid Metabolism 8 45.28 Quite Low
Rickets 16 23.80 Low Low
Cardiovascular Disease 2 12.12 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 6.48 Low Low
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Cancer 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we discuss the crosstalk between SXR and CAR, FXR and VDR, all of which appear to be important for xenobiotic, bile acid, or vitamin D metabolism and disposition.
FXR Binding (crosstalk) of in CAR associated with bile
1) Confidence 0.13 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.08
Four FXR binding elements were identified in the SXR promoter; two of these were able to bind FXR protein and trigger a strong response to ligand treatment.
FXR protein Binding (bind) of
2) Confidence 0.12 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.18 Pain Relevance 0.36

General Comments

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