INT262107

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 6.56
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) cell morphogenesis (Vdr) nucleus (Vdr)
DNA binding (Vdr)
Anatomy Link Frequency
neck 1
CAR 1
skeletal muscle 1
immune system 1
body 1
Vdr (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 119 97.84 Very High Very High Very High
Multiple sclerosis 1 96.76 Very High Very High Very High
Arthritis 2 95.24 Very High Very High Very High
agonist 16 63.16 Quite High
antagonist 13 52.76 Quite High
rheumatoid arthritis 1 29.44 Quite Low
Inflammation 21 5.00 Very Low Very Low Very Low
Pain 13 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress Fractures 371 99.76 Very High Very High Very High
Obesity 276 99.48 Very High Very High Very High
Body Weight 64 98.32 Very High Very High Very High
Multiple Sclerosis 3 96.76 Very High Very High Very High
Diabetes Mellitus 14 95.80 Very High Very High Very High
Arthritis 2 95.24 Very High Very High Very High
Asthma 5 94.52 High High
Frailty 73 94.12 High High
Hypophosphatemia 27 91.60 High High
Disease 63 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VDR, CTR, and IL-6 SNPs, did not significantly associate with stress fracture in any genetic model (Table 3).


VDR Binding (associate) of associated with stress fractures
1) Confidence 0.48 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.66 Pain Relevance 0
No association between the VDR haplotypes and stress fractures was detected.
VDR Neg (No) Binding (association) of associated with stress fractures
2) Confidence 0.48 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.55 Pain Relevance 0
The present study indicates that the association of the LRP5 haplotype and LRP5-VDR interaction with stress fractures is mediated by low body weight and BMI, but more research is needed before any definitive conclusions can be drawn from these findings.
LRP5-VDR Binding (interaction) of in body associated with body weight, obesity and stress fractures
3) Confidence 0.48 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.97 Pain Relevance 0
Genotyping of the VDR, CTR, and IL-6 variations was performed as described previously [16,18,21,24,25].
VDR Binding (Genotyping) of
4) Confidence 0.37 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.07 Pain Relevance 0
Genotyping of 15 SNPs in the VDR, CTR, IL-6, COL1A1, COL1A2, and LRP5 genes
VDR Binding (Genotyping) of
5) Confidence 0.37 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.26 Pain Relevance 0
G: 178.8 ± 6.2 cm, p = 0.025), and the VDR BsmI minor allele A was associated with higher BMI (A: 23.7 ± 3.7 kg/m2 vs.
VDR Binding (associated) of associated with obesity
6) Confidence 0.37 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.77 Pain Relevance 0
The most important physical variable was weight, because reduced weight and BMI mediate the association of the LRP5 haplotype and the LRP5-VDR interaction with femoral neck stress fractures.
LRP5-VDR Binding (interaction) of in neck associated with obesity and stress fractures
7) Confidence 0.36 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.85 Pain Relevance 0
Calcitriol, active metabolite of vitamin D, acts in the immune system through its specific intracellular receptor (VDR) and has been recently shown to have influence in experimental murine models of multiple sclerosis [6], diabetes [7], arthritis [8] and asthma [9] with a shift in Th1/Th2 balance.
VDR Binding (receptor) of in immune system associated with asthma, multiple sclerosis, diabetes mellitus and arthritis
8) Confidence 0.24 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.68 Pain Relevance 0.10
The ligand-bound VDR forms a heterodimer with retinoid X receptors (RXRs) and induces the expression of Fgf23.
VDR Binding (bound) of
9) Confidence 0.23 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.12 Pain Relevance 0.14
(Fgf23) Active vitamin D binds the vitamin D receptor (VDR).
vitamin D receptor Binding (binds) of
10) Confidence 0.22 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.14
Active vitamin D binds the vitamin D receptor (VDR).
VDR Binding (binds) of
11) Confidence 0.22 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.13 Pain Relevance 0.06
(Fgf23) Active vitamin D binds the vitamin D receptor (VDR).
VDR Binding (binds) of
12) Confidence 0.22 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.14
Active vitamin D binds the vitamin D receptor (VDR).
vitamin D receptor Binding (binds) of
13) Confidence 0.22 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.13 Pain Relevance 0.06
Here we discuss the crosstalk between SXR and CAR, FXR and VDR, all of which appear to be important for xenobiotic, bile acid, or vitamin D metabolism and disposition.
VDR Binding (crosstalk) of in CAR associated with bile
14) Confidence 0.22 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.08
Vitamin D binding to the vitamin D receptor found in skeletal muscle promotes muscle protein synthesis and enhances calcium uptake across the cell membrane.80 Low vitamin D levels result in atrophy predominantly of the type 2 (fast twitch) muscle fibers in common with sarcopenia.81 Low levels of vitamin D have been found to be associated with an increase in sarcopenia.82 A myopathy has been reported in severe vitamin D deficiency.83 In older people low vitamin D levels may produce functional problems including proximal muscle weakness, difficultly rising from a chair, difficulties in ascending stairs, and axial balance problems.84
vitamin D receptor Binding (binding) of in skeletal muscle associated with muscle weakness, muscle disease and frailty
15) Confidence 0.04 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2938029 Disease Relevance 0.86 Pain Relevance 0

General Comments

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