INT262117

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.91
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp7a1) endoplasmic reticulum (Cyp7a1) lipid metabolic process (Cyp7a1)
Anatomy Link Frequency
bile 6
Cyp7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 108 100.00 Very High Very High Very High
Bile 105 100.00 Very High Very High Very High
Inflammation 76 5.00 Very Low Very Low Very Low
antagonist 17 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Endocannabinoid 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 34 84.76 Quite High
Disorder Of Lipid Metabolism 50 74.04 Quite High
Toxicity 8 73.16 Quite High
Hepatotoxicity 4 56.28 Quite High
Colon Cancer 7 42.36 Quite Low
Liver Disease 5 41.68 Quite Low
Obesity 42 28.64 Quite Low
Osteoporosis 14 23.56 Low Low
Hypoglycemia 6 10.76 Low Low
INFLAMMATION 72 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Cyp7a1, which represents the rate-limiting enzyme in bile acid synthesis, is markedly downregulated in PPAR??
Negative_regulation (downregulated) of Gene_expression (Expression) of Cyp7a1 in bile associated with bile
1) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.15 Pain Relevance 0.31
agonists reduce Cyp7a1 expression in both mice and human [145, 238–240].
Negative_regulation (sts re) of Gene_expression (7a1 expres) of Cyp7a1 associated with agonist
2) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.13 Pain Relevance 0.35
Bile acid activated FXR represses the expression of CYP7A1 and CYP2B, enzymes involved in bile acid synthesis, through an indirect mechanism.
Negative_regulation (represses) of Gene_expression (expression) of CYP7A1 in bile associated with bile
3) Confidence 0.21 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.23
Activation of SXR downregulated expression of CYP7A1, the first and rate limiting step in the metabolism of cholesterol to bile acids [Staudinger et al., 2001; Xie et al., 2001].
Negative_regulation (downregulated) of Gene_expression (expression) of CYP7A1 in bile associated with bile
4) Confidence 0.21 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.36 Pain Relevance 0.36
agonists reduce Cyp7a1 expression in both mice and human [145, 238–240].
Negative_regulation (reduce) of Gene_expression (7a1 expres) of Cyp7a1 associated with agonist
5) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.13 Pain Relevance 0.35

General Comments

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