INT262118

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Nr5a2) nucleus (Nr5a2) DNA binding (Nr5a2)
cytoplasm (Nr5a2)
Anatomy Link Frequency
liver 4
Nr5a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 117 97.98 Very High Very High Very High
agonist 27 51.84 Quite High
Inflammation 51 5.00 Very Low Very Low Very Low
antagonist 21 5.00 Very Low Very Low Very Low
Crohn's disease 18 5.00 Very Low Very Low Very Low
antidepressant 9 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Taxol 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
carbamazepine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 51 63.60 Quite High
Toxicity 12 20.72 Low Low
Inflammatory Bowel Disease 96 5.00 Very Low Very Low Very Low
Cancer 54 5.00 Very Low Very Low Very Low
INFLAMMATION 36 5.00 Very Low Very Low Very Low
Disease 30 5.00 Very Low Very Low Very Low
Rickets 24 5.00 Very Low Very Low Very Low
Breast Cancer 24 5.00 Very Low Very Low Very Low
Osteoporosis 21 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
Negative_regulation (inhibits) of LRH-1 Binding (activity) of in liver associated with bile
1) Confidence 0.07 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.12 Pain Relevance 0.23
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
Negative_regulation (inhibits) of receptor homolog-1 Binding (activity) of in liver associated with bile
2) Confidence 0.07 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.12 Pain Relevance 0.23
In addition to inhibiting the activity of LRH-1, SHP can also interact with SXR and inhibit its transcriptional activity [Ourlin et al., 2003].
Negative_regulation (inhibiting) of LRH-1 Binding (activity) of
3) Confidence 0.07 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.11 Pain Relevance 0.25

General Comments

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