INT262123

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 6.67
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp24a1) oxidoreductase activity (Cyp24a1)
Anatomy Link Frequency
liver 3
intestine 3
kidney 3
Cyp24a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 148 99.20 Very High Very High Very High
Inflammation 272 96.32 Very High Very High Very High
antiepileptic Drug 16 87.76 High High
carbamazepine 16 82.96 Quite High
Bile 688 78.36 Quite High
Inflammatory stimuli 16 68.96 Quite High
anticonvulsant 16 53.60 Quite High
antagonist 112 5.00 Very Low Very Low Very Low
Crohn's disease 96 5.00 Very Low Very Low Very Low
antidepressant 48 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 420 99.16 Very High Very High Very High
Rickets 200 98.58 Very High Very High Very High
Inflammatory Bowel Disease 512 96.32 Very High Very High Very High
INFLAMMATION 192 90.32 High High
Infection 32 88.96 High High
Metabolic Bone Disease 16 85.36 High High
Obesity 68 79.84 Quite High
Disease 184 79.60 Quite High
Extrahepatic Cholestasis 4 73.84 Quite High
Pancreatic Cancer 4 70.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased Fgf23 suppresses the expression of Cyp27b1 and induces the expression of Cyp24 by activating the ?
Gene_expression (expression) of Cyp24
1) Confidence 0.67 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.20 Pain Relevance 0.10
The Fgf23 suppresses the expression of Cyp27b1 and induces the expression of Cyp24 in the kidney (Shimada et al 2004).
Gene_expression (expression) of Cyp24 in kidney
2) Confidence 0.52 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.23 Pain Relevance 0.03
Cyp27b1 and Cyp24 encode enzymes, 1a-hydroxylase and 24-hydroxylase, which synthesize and inactivate active vitamin D, respectively.
Gene_expression (synthesize) of 24-hydroxylase
3) Confidence 0.52 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.26 Pain Relevance 0
The suppression of Cyp27b1 expression and induction of Cyp24 expression by Fgf23 result in decreased levels of active vitamin D in serum.
Gene_expression (expression) of Cyp24
4) Confidence 0.52 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.33 Pain Relevance 0.03
In addition, CYP24 is expressed at very low levels in liver and intestine where SXR is abundant [Xu et al., 2006].
Gene_expression (expressed) of CYP24 in intestine
5) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.41 Pain Relevance 0.05
However, this model is of questionable significance with regard to the physiological functions of CYP24 in vivo, because CYP24 is found primarily in the kidney, where SXR is expressed at very low levels.
Gene_expression (found) of CYP24 in kidney
6) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.42 Pain Relevance 0.06
This provided a mechanism to explain the low levels of CYP24 expression in tissues containing high levels of SXR. 1,25(OH)2D3-induced CYP24 expression was enhanced in SXR knockout mice, and treatment of humans with the SXR agonist rifampicin had no effect on intestinal CYP24 expression, despite marked CYP3A4 induction [Zhou et al., 2006a].
Gene_expression (expression) of CYP24 associated with targeted disruption and agonist
7) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.05
It upregulates CYP3A4 expression, while repressing CYP24 and CYP2D25 expression in the liver and intestine.


Gene_expression (expression) of CYP24 in intestine
8) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.68 Pain Relevance 0.18
To reveal the mechanism of drug-induced osteomalacia, several groups recently investigated the impact of SXR activation on CYP24 gene expression in vitro and in vivo.
Gene_expression (expression) of CYP24 gene associated with rickets
9) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.44 Pain Relevance 0.08
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Gene_expression (expression) of CYP24 in intestine
10) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.21 Pain Relevance 0.04
This suggests that enhanced CYP24 expression by SXR is unlikely to play an important role in the development of osteomalacia following long-term treatment with SXR activators.
Gene_expression (expression) of CYP24 associated with rickets
11) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.40 Pain Relevance 0
It was later shown that activation of SXR did not induce CYP24 expression in vitro or in vivo, nor did it transactivate the CYP24 promoter [Zhou et al., 2006a].
Gene_expression (expression) of CYP24
12) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.03
Pascussi et al. first suggested that activation of SXR can enhance the expression of the VDR target gene, CYP24, which would increase the catabolism of 1,25(OH)2D3; thereby, leading to drug-induced osteomalacia [Pascussi et al., 2005].
Gene_expression (expression) of CYP24 associated with rickets
13) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.44 Pain Relevance 0.08
This provided a mechanism to explain the low levels of CYP24 expression in tissues containing high levels of SXR. 1,25(OH)2D3-induced CYP24 expression was enhanced in SXR knockout mice, and treatment of humans with the SXR agonist rifampicin had no effect on intestinal CYP24 expression, despite marked CYP3A4 induction [Zhou et al., 2006a].
Gene_expression (expression) of CYP24 associated with targeted disruption and agonist
14) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.05
They conducted a series of in vitro and in vivo studies which were interpreted as providing evidence that a drug, which can activate SXR is likely to enhance CYP24 expression and the catabolism of 25(OH)D3, leading to vitamin D deficiency.
Gene_expression (expression) of CYP24
15) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.44 Pain Relevance 0.06
Although there is also a relatively high level of VDR expression in the small intestine, constitutive CYP24 expression in this tissue is very low or undetectable, in contrast to that in the kidney [Xu et al., 2006].
Gene_expression (expression) of CYP24 in kidney
16) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.33 Pain Relevance 0.21
This provided a mechanism to explain the low levels of CYP24 expression in tissues containing high levels of SXR. 1,25(OH)2D3-induced CYP24 expression was enhanced in SXR knockout mice, and treatment of humans with the SXR agonist rifampicin had no effect on intestinal CYP24 expression, despite marked CYP3A4 induction [Zhou et al., 2006a].
Gene_expression (expression) of CYP24 associated with targeted disruption and agonist
17) Confidence 0.44 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.05
In addition, CYP24 is expressed at very low levels in liver and intestine where SXR is abundant [Xu et al., 2006].
Gene_expression (expressed) of CYP24 in liver
18) Confidence 0.15 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.41 Pain Relevance 0.05
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Gene_expression (expression) of CYP24 in liver
19) Confidence 0.15 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.21 Pain Relevance 0.04
It upregulates CYP3A4 expression, while repressing CYP24 and CYP2D25 expression in the liver and intestine.


Gene_expression (expression) of CYP24 in liver
20) Confidence 0.15 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.68 Pain Relevance 0.18

General Comments

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