INT262127

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 6.92
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Anatomy Link Frequency
gut 4
liver 3
colon 2
bile 2
small intestine 1
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 22 97.08 Very High Very High Very High
Bile 429 96.76 Very High Very High Very High
agonist 99 95.04 Very High Very High Very High
Inflammation 187 86.56 High High
Crohn's disease 66 70.64 Quite High
Taxol 22 51.36 Quite High
antidepressant 33 44.64 Quite Low
Analgesic 11 33.72 Quite Low
palliative 11 31.88 Quite Low
antagonist 77 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 187 100.00 Very High Very High Very High
Endometriosis (extended) 33 99.84 Very High Very High Very High
Inflammatory Bowel Disease 352 99.68 Very High Very High Very High
Apoptosis 55 97.56 Very High Very High Very High
Hepatotoxicity 22 88.32 High High
Osteogenic Sarcomas 55 85.04 High High
Repression 33 84.08 Quite High
Cancer 198 80.16 Quite High
Toxicity 44 73.32 Quite High
Disease 110 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies by this group showed that when SXR expression is downregulated in endometrial cancer cells, the cell growth inhibitory and apoptotic activities of anticancer agents that activate SXR, such as paclitaxel and cisplatin, are significantly enhanced.
Negative_regulation (downregulated) of Gene_expression (expression) of SXR associated with endometriosis (extended) and apoptosis
1) Confidence 0.55 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.67 Pain Relevance 0.05
In both models, complete gene disruption was confirmed by the absence of SXR expression in the liver and small intestine where it is predominantly expressed; although, there are subtle phenotypic differences between the two types of mice.
Negative_regulation (absence) of Gene_expression (expression) of SXR in liver
2) Confidence 0.55 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.40 Pain Relevance 0.14
Although the downregulation of MDR1 in IBD patients may be independent of the decreased expression of SXR, these data are consistent with the possibility that dysregulation of SXR in the gut is likely to contribute to the pathophysiology of ulcerative colitis.
Negative_regulation (decreased) of Gene_expression (expression) of SXR in gut associated with inflammatory bowel disease
3) Confidence 0.41 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.54 Pain Relevance 0.20
A 6-bp deletion in the promoter region of NR1I2 at a putative hepatic nuclear factor binding site was suggested to have a possible influence on the promoter region and potentially inhibit SXR promoter activity and downregulate expression of SXR target genes [Lamba et al., 2008; Uno et al., 2003].
Negative_regulation (inhibit) of Gene_expression (expression) of SXR
4) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.17 Pain Relevance 0.04
Although the downregulation of MDR1 in IBD patients may be independent of the decreased expression of SXR, these data are consistent with the possibility that dysregulation of SXR in the gut is likely to contribute to the pathophysiology of ulcerative colitis.
Negative_regulation (decreased) of Gene_expression (expression) of SXR in gut associated with inflammatory bowel disease
5) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.33 Pain Relevance 0.17
Activation of SXR downregulated expression of CYP7A1, the first and rate limiting step in the metabolism of cholesterol to bile acids [Staudinger et al., 2001; Xie et al., 2001].
Negative_regulation (downregulated) of Gene_expression (expression) of SXR in bile associated with bile
6) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.36 Pain Relevance 0.36
SOD and CAT may not be direct transcriptional targets of SXR and the mechanism of SXR-mediated downregulation of SOD and CAT activities remains to be determined.
Negative_regulation (mechanism) of Gene_expression (targets) of SXR
7) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.24 Pain Relevance 0.05
A 6-bp deletion in the promoter region of NR1I2 at a putative hepatic nuclear factor binding site was suggested to have a possible influence on the promoter region and potentially inhibit SXR promoter activity and downregulate expression of SXR target genes [Lamba et al., 2008; Uno et al., 2003].
Negative_regulation (inhibit) of Gene_expression (expression) of SXR
8) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.17 Pain Relevance 0.04
Targeted disruption of SXR abolishes the induction of CYP3A genes in response to prototypic inducers such as dexamethasone or PCN.
Negative_regulation (abolishes) of Gene_expression (disruption) of SXR associated with targeted disruption and dexamethasone
9) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.40 Pain Relevance 0.20
They further showed, using DNA microarray analyses of nonaffected tissue from IBD patients, that expression of SXR and a known target gene, MDR1, were downregulated in the colon of ulcerative colitis patients.
Negative_regulation (downregulated) of Gene_expression (expression) of SXR in colon associated with inflammatory bowel disease
10) Confidence 0.40 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.25 Pain Relevance 0.19
In both models, complete gene disruption was confirmed by the absence of SXR expression in the liver and small intestine where it is predominantly expressed; although, there are subtle phenotypic differences between the two types of mice.
Negative_regulation (absence) of in small intestine Gene_expression (expression) of SXR in liver
11) Confidence 0.19 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.40 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox