INT262141

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Edcs1 (Rattus norvegicus)
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 14 79.32 Quite High
agonist 18 42.80 Quite Low
Bile 78 5.00 Very Low Very Low Very Low
Inflammation 34 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 36.64 Quite Low
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Cancer 36 5.00 Very Low Very Low Very Low
Targeted Disruption 34 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Rickets 16 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low
Osteoporosis 14 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since many EDCs can activate SXR and thereby influence their own metabolism as well as the metabolism of other xenobiotic and endobiotic compounds, it will be important to investigate the effects of systemic exposures to EDCs on SXR activity and characterize the in vivo pharmacokinetic effects on other compounds.
EDCs Positive_regulation (activate) of SXR
1) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0.03
Given that EDCs and other xenobiotic compounds can both activate and antagonize SXR, it will be increasingly important to understand the effects of mixtures in order to predict the effects of real-world chemical exposure.


EDCs Positive_regulation (activate) of SXR
2) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox