INT262143

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2d9) endoplasmic reticulum (Cyp2d9) nucleus (Nr1i2)
DNA binding (Nr1i2)
Nr1i2 (Mus musculus)
Cyp2d9 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 83.72 Quite High
Inflammation 17 51.20 Quite High
Inflammatory stimuli 1 23.84 Low Low
anticonvulsant 1 8.48 Low Low
Bile 39 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 8 82.48 Quite High
Targeted Disruption 17 81.68 Quite High
Inflammatory Bowel Disease 32 51.20 Quite High
INFLAMMATION 12 45.20 Quite Low
Infection 2 43.84 Quite Low
Cancer 18 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Osteoporosis 7 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, phenobarbital-activated SXR can also inhibit expression of CYP2D25 at the transcriptional level [Hosseinpour et al., 2007].
Positive_regulation (activated) of SXR Negative_regulation (inhibit) of Gene_expression (expression) of CYP2D25
1) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.28 Pain Relevance 0.07

General Comments

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