INT262144

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h4, Nr1i2) DNA binding (Nr1h4, Nr1i2)
Anatomy Link Frequency
bile 2
Nr1h4 (Mus musculus)
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 39 100.00 Very High Very High Very High
agonist 9 83.52 Quite High
antiepileptic Drug 1 14.80 Low Low
carbamazepine 1 10.00 Low Low
Inflammation 17 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 99.12 Very High Very High Very High
Targeted Disruption 17 87.20 High High
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Rickets 8 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Osteoporosis 7 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bile acids activate FXR, which downregulates synthesis of bile acids and also leads to the transcriptional activation of SXR, thereby promoting bile acid metabolism.


FXR Positive_regulation (leads) of Positive_regulation (activation) of SXR in bile associated with bile
1) Confidence 0.19 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.19 Pain Relevance 0.27

General Comments

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