INT262153

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Anatomy Link Frequency
liver 1
Clta (Mus musculus)
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 39 100.00 Very High Very High Very High
inflammatory 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Antidepressant 3 5.00 Very Low Very Low Very Low
Dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Carbamazepine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 4 100.00 Very High Very High Very High
Targeted Disruption 17 93.76 High High
Hepatotoxicity 2 86.52 High High
Colon Cancer 2 72.60 Quite High
Liver Disease 1 71.92 Quite High
Osteoporosis 7 53.80 Quite High
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that SXR plays an important role in bile acid metabolism and protects against LCA toxicity in mouse liver.
LCA Binding (toxicity) of SXR in liver associated with toxicity and bile
1) Confidence 0.05 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.65 Pain Relevance 0.38

General Comments

This test has worked.

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