INT262157

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Plec) plasma membrane (Plec) cytoskeleton (Plec)
nucleus (Nr1i2) DNA binding (Nr1i2) cytoplasm (Plec)
Anatomy Link Frequency
liver 1
intestine 1
Nr1i2 (Mus musculus)
Plec (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 18 93.12 High High
Inflammation 34 29.44 Quite Low
Bile 78 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 34 91.08 High High
Rickets 16 60.72 Quite High
Inflammatory Bowel Disease 64 29.44 Quite Low
INFLAMMATION 24 23.44 Low Low
Infection 4 22.08 Low Low
Cancer 36 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low
Osteoporosis 14 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
SXR Binding (ligand) of PCN in intestine
1) Confidence 0.03 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.05
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
SXR Binding (ligand) of PCN in liver
2) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.05

General Comments

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