INT262165

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.50
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr0b2, Nr5a2) DNA binding (Nr0b2, Nr5a2) cytoplasm (Nr0b2, Nr5a2)
lipid binding (Nr5a2) protein complex (Nr0b2) transcription factor binding (Nr0b2)
Anatomy Link Frequency
liver 4
Nr0b2 (Mus musculus)
Nr5a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 156 99.02 Very High Very High Very High
agonist 36 45.20 Quite Low
Inflammation 68 5.00 Very Low Very Low Very Low
antagonist 28 5.00 Very Low Very Low Very Low
Crohn's disease 24 5.00 Very Low Very Low Very Low
antidepressant 12 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Taxol 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
carbamazepine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 68 65.68 Quite High
Toxicity 16 14.08 Low Low
Inflammatory Bowel Disease 128 5.00 Very Low Very Low Very Low
Cancer 72 5.00 Very Low Very Low Very Low
INFLAMMATION 48 5.00 Very Low Very Low Very Low
Disease 40 5.00 Very Low Very Low Very Low
Rickets 32 5.00 Very Low Very Low Very Low
Breast Cancer 32 5.00 Very Low Very Low Very Low
Osteoporosis 28 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
small heterodimer partner Negative_regulation (inhibits) of LRH-1 in liver associated with bile
1) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.13 Pain Relevance 0.23
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
small heterodimer partner Negative_regulation (inhibits) of receptor homolog-1 in liver associated with bile
2) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.13 Pain Relevance 0.23
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
SHP Negative_regulation (inhibits) of receptor homolog-1 in liver associated with bile
3) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.12 Pain Relevance 0.23
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
SHP Negative_regulation (inhibits) of LRH-1 in liver associated with bile
4) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.12 Pain Relevance 0.23

General Comments

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