INT262169

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxa2, Nr1i2) DNA binding (Foxa2, Nr1i2) anatomical structure formation involved in morphogenesis (Foxa2)
transcription factor binding (Foxa2) cytoplasm (Foxa2)
Anatomy Link Frequency
livers 1
Foxa2 (Mus musculus)
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 28.08 Quite Low
Bile 78 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 99.00 Very High Very High Very High
Insulin Resistance 2 72.96 Quite High
Diabetes Mellitus 6 71.12 Quite High
INFLAMMATION 24 28.08 Quite Low
Cancer 36 21.92 Low Low
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Targeted Disruption 34 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Rickets 16 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nakamura et al. reported that SXR can crosstalk with FoxA2 to mediate drug-induced repression of lipid metabolism in fasting mouse livers [Kiyosawa et al., 2004].
FoxA2 Binding (crosstalk) of SXR in livers associated with repression
1) Confidence 0.17 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.10 Pain Relevance 0
The SXR ligand binding domain can directly interact with DNA-binding domain of FoxA2 and this interaction prevents the binding of FoxA2 to its response elements in target genes.
FoxA2 Binding (interact) of SXR
2) Confidence 0.14 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.23 Pain Relevance 0

General Comments

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