INT26217

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 5.22
Pain Relevance 12.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) extracellular region (Calca) nucleus (Calca)
intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
IB4 2
macrophages 1
nasal 1
sympathetic 1
skin 1
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 203 100.00 Very High Very High Very High
Calcitonin gene-related peptide 196 100.00 Very High Very High Very High
Neuropeptide 178 99.98 Very High Very High Very High
Morphine 93 99.76 Very High Very High Very High
Opioid 21 99.76 Very High Very High Very High
Enkephalin 18 99.56 Very High Very High Very High
opiate 6 99.24 Very High Very High Very High
MU agonist 5 98.96 Very High Very High Very High
Antinociceptive 8 98.40 Very High Very High Very High
Nerve growth factor 45 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 2 100.00 Very High Very High Very High
Pruritus 86 99.48 Very High Very High Very High
Nociception 37 99.28 Very High Very High Very High
Sneezing 4 99.00 Very High Very High Very High
Cancer 101 97.24 Very High Very High Very High
Psoriasis 60 95.76 Very High Very High Very High
Pain 31 95.76 Very High Very High Very High
Ganglion Cysts 108 95.04 Very High Very High Very High
Eczema 30 94.80 High High
Immunotherapy Of Cancer 6 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CGRP does not appear to interact directly with the opiate receptor because it does not mimic the activity of naloxone i.t.
CGRP Neg (not) Binding (interact) of associated with narcan, opiate and calcitonin gene-related peptide
1) Confidence 0.48 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2552070 Disease Relevance 0 Pain Relevance 1.96
The aim of this study was to investigate the possible interaction of CGRP with morphine on nociception in adult male NMRI mice after central administration of the peptide.
CGRP Binding (interaction) of associated with nociception, morphine and calcitonin gene-related peptide
2) Confidence 0.42 Published 1995 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8545480 Disease Relevance 0.28 Pain Relevance 1.06
Calcitonin gene-related peptide (CGRP) is a polypeptide produced by alternative processing of calcitonin gene transcripts and is endowed with important systemic physiological effects.
Calcitonin Binding (endowed) of associated with calcitonin gene-related peptide
3) Confidence 0.37 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19860701 Disease Relevance 0.14 Pain Relevance 0.38
Calcitonin gene-related peptide (CGRP) is a polypeptide produced by alternative processing of calcitonin gene transcripts and is endowed with important systemic physiological effects.
CGRP Binding (endowed) of associated with calcitonin gene-related peptide
4) Confidence 0.37 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19860701 Disease Relevance 0.14 Pain Relevance 0.38
In addition to this extensive set of sensory and sympathetic nerve fibers that terminate in the pancreas, there were large bundles of en passant nerve fibers in the dorsal region of the pancreas that expressed RT97 or CGRP and were associated with the superior mesenteric plexus.
CGRP Binding (associated) of in sympathetic associated with calcitonin gene-related peptide
5) Confidence 0.36 Published 2006 Journal Neuroscience Section Abstract Doc Link 16388907 Disease Relevance 0.16 Pain Relevance 0.33
In vitro study of the interaction of salmon calcitonin with mu, delta and kappa opioid agonists.
calcitonin Binding (interaction) of associated with mu agonist and enkephalin
6) Confidence 0.36 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8386807 Disease Relevance 0 Pain Relevance 0.79
Accordingly, we investigated if NPY- and CGRP-related peptides modulate cognitive processes by interacting with sigma sites in mice.
CGRP Binding (interacting) of associated with cognitive disorder and calcitonin gene-related peptide
7) Confidence 0.33 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9421174 Disease Relevance 0.10 Pain Relevance 0.73
Calcitonin gene-related peptide (CGRP) is a polypeptide produced by alternative processing of calcitonin gene transcripts and is endowed with important systemic physiological effects.
gene-related peptide Binding (endowed) of associated with calcitonin gene-related peptide
8) Confidence 0.33 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19860701 Disease Relevance 0.14 Pain Relevance 0.38
(rabbit, 1:50; Santa Cruz Biotechnology; mouse, 1:50; BD Transduction Laboratories), CGRP (rabbit, 1:1000; Sigma), NeuN (mouse, 1:100; Chemicon), GFAP (mouse, 1:400; Chemicon) and Iba 1 (rabbit, 1:500, Wako Pure Chemical Industries, Ltd., Osaka, Japan).
CGRP Binding (rabbit) of associated with calcitonin gene-related peptide
9) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.09 Pain Relevance 0.10
Enzyme-immuno assay for CGRP
CGRP Binding (assay) of
10) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2672059 Disease Relevance 0 Pain Relevance 0
A possible interaction of salmon-calcitonin with opioid systems was studied in isolated tissues.
salmon-calcitonin Binding (interaction) of associated with opioid
11) Confidence 0.16 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8386807 Disease Relevance 0 Pain Relevance 0.38
Outside the immune system, the direct interaction of nerve endings containing SP and CGRP with DCs has been described in the skin and in the airway epithelium [8,9].
CGRP Binding (interaction) of in skin associated with calcitonin gene-related peptide and substance p
12) Confidence 0.15 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0 Pain Relevance 0.65
Within these secondary immune organs, SP and CGRP containing afferent nerve endings of the NANC system terminate around high endothelial venules, the sites of specialised extravasation of recirculating T cells, and in the T cell area and lymphoid follicles, interacting with T cells, macrophages, mast cells and possibly DCs [6,7].
CGRP Binding (interacting) of in macrophages associated with calcitonin gene-related peptide and substance p
13) Confidence 0.15 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.05 Pain Relevance 0.65
expression of SP receptor, TrkA and CGRP receptor, but the immunoreactivity for
CGRP Binding (receptor) of associated with calcitonin gene-related peptide and substance p
14) Confidence 0.14 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2221678 Disease Relevance 0.89 Pain Relevance 0.65
No deficits are apparent in IB4 binding or CGRP-immunoreactive neurons.
CGRP Binding (binding) of in IB4 associated with calcitonin gene-related peptide
15) Confidence 0.12 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.06 Pain Relevance 0.09
Accordingly, a combination of microCT with microPET will allow a sensitive and accurate quantification of tumor burden in mice and be valuable for the evaluation of novel cancer treatments.


microCT Binding (combination) of associated with cancer and immunotherapy of cancer
16) Confidence 0.06 Published 2008 Journal BMC Med Imaging Section Body Doc Link PMC2575188 Disease Relevance 1.24 Pain Relevance 0.24
Few thrombin-responsive neurons were IB4-positive (Fig. 2 and Fig. 6B), and small thrombin-responsive neurons express the neuropeptides CGRP and SP (Fig. 6) which are known not to be colocalized with IB4 binding.
CGRP Binding (binding) of in IB4 associated with neuropeptide, substance p and calcitonin gene-related peptide
17) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.28 Pain Relevance 0.75
Within these secondary immune organs, SP and CGRP containing afferent nerve endings of the NANC system terminate around high endothelial venules, the sites of specialised extravasation of recirculating T cells, and in the T cell area and lymphoid follicles, interacting with T cells, macrophages, mast cells and possibly DCs [6,7].
CGRP Binding (interacting) of in T cells associated with calcitonin gene-related peptide and substance p
18) Confidence 0.05 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.05 Pain Relevance 0.65
Within these secondary immune organs, SP and CGRP containing afferent nerve endings of the NANC system terminate around high endothelial venules, the sites of specialised extravasation of recirculating T cells, and in the T cell area and lymphoid follicles, interacting with T cells, macrophages, mast cells and possibly DCs [6,7].
CGRP Binding (interacting) of in mast cells associated with calcitonin gene-related peptide and substance p
19) Confidence 0.05 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.05 Pain Relevance 0.65
The interaction of intraperitoneal administration of salmon-calcitonin with opioids was studied.
salmon-calcitonin Binding (interaction) of associated with opioid
20) Confidence 0.04 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 8745158 Disease Relevance 0 Pain Relevance 0.52

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