INT262170

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp24a1) oxidoreductase activity (Cyp24a1) nucleus (Nr1i2)
DNA binding (Nr1i2)
Nr1i2 (Mus musculus)
Cyp24a1 (Mus musculus)
Pain Link Frequency Relevance Heat
carbamazepine 1 47.76 Quite Low
antiepileptic Drug 1 45.60 Quite Low
Bile 39 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 8 97.56 Very High Very High Very High
Metabolic Bone Disease 1 51.04 Quite High
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
Targeted Disruption 17 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Osteoporosis 7 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that enhanced CYP24 expression by SXR is unlikely to play an important role in the development of osteomalacia following long-term treatment with SXR activators.
SXR Positive_regulation (enhanced) of Gene_expression (expression) of CYP24 associated with rickets
1) Confidence 0.29 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.40 Pain Relevance 0

General Comments

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