INT262176

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) plasma membrane (Casr) nucleus (Nr1i2)
DNA binding (Nr1i2) signal transducer activity (Casr)
Anatomy Link Frequency
CAR 2
Nr1i2 (Mus musculus)
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 17 85.60 High High
Bile 39 59.52 Quite High
agonist 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 32 86.36 High High
Cancer 18 39.12 Quite Low
Lung Cancer 1 34.00 Quite Low
Targeted Disruption 17 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Rickets 8 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Osteoporosis 7 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a detailed study comparing the activity of all SXR SNPs toward ligand activation and the potential interactions between these SNPs and the ability of SXR to modulate the activity of CAR and other transcription factors remains to be performed.
SXR Regulation (modulate) of Regulation (activity) of CAR in CAR
1) Confidence 0.11 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.17 Pain Relevance 0.07

General Comments

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