INT262186

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp7a1) endoplasmic reticulum (Cyp7a1) nucleus (Nr0b2)
DNA binding (Nr0b2) protein complex (Nr0b2) transcription factor binding (Nr0b2)
Nr0b2 (Mus musculus)
Cyp7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 39 97.92 Very High Very High Very High
Inflammation 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 17 78.32 Quite High
Toxicity 4 66.72 Quite High
Hepatotoxicity 2 49.84 Quite Low
Colon Cancer 2 35.92 Quite Low
Liver Disease 1 35.24 Quite Low
Osteoporosis 7 17.12 Low Low
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of CYP7A1 is not mediated through SHP as in the case for FXR.
SHP Neg (not) Positive_regulation (mediated) of Negative_regulation (Inhibition) of CYP7A1
1) Confidence 0.12 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.28 Pain Relevance 0.40

General Comments

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