INT262190

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Foxo1, Pck1) nucleus (Foxo1, Pck1) lyase activity (Pck1)
embryo development (Foxo1) DNA binding (Foxo1) lipid metabolic process (Pck1)
Anatomy Link Frequency
liver 2
Foxo1 (Mus musculus)
Pck1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 14 61.88 Quite High
Bile 78 5.00 Very Low Very Low Very Low
Inflammation 34 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 77.44 Quite High
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Cancer 36 5.00 Very Low Very Low Very Low
Targeted Disruption 34 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Rickets 16 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low
Osteoporosis 14 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FoxO1 promotes gluconeogenesis in liver in the fasted state by activating gluconeogenic genes, such as phosphoenolpyruvate carboxykinase 1 (PEPCK1), glucose-6-phosphatase (G6P) and insulin-like growth factor-binding protein 1.
FoxO1 Positive_regulation (activating) of phosphoenolpyruvate carboxykinase 1 in liver
1) Confidence 0.04 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.08 Pain Relevance 0.03
FoxO1 promotes gluconeogenesis in liver in the fasted state by activating gluconeogenic genes, such as phosphoenolpyruvate carboxykinase 1 (PEPCK1), glucose-6-phosphatase (G6P) and insulin-like growth factor-binding protein 1.
FoxO1 Positive_regulation (activating) of PEPCK1 in liver
2) Confidence 0.04 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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