INT262197

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) nucleus (Nr1i2) DNA binding (Nr1i2)
lipid metabolic process (Insig1)
Anatomy Link Frequency
CAR 1
Nr1i2 (Mus musculus)
Insig1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 53 86.80 High High
Crohn's disease 7 15.16 Low Low
Inflammation 18 12.64 Low Low
agonist 9 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 4 47.20 Quite Low
Targeted Disruption 17 41.68 Quite Low
Neurodegenerative Disease 1 36.68 Quite Low
Van Bogaert's Disease 1 35.52 Quite Low
Disease 11 15.16 Low Low
Diabetes Mellitus 4 14.36 Low Low
Obesity 3 13.68 Low Low
INFLAMMATION 13 12.64 Low Low
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This report elegantly provided an explanation as to how an activation of xenobiotic metabolism regulators like CAR and PXR induce Insig-1 by CAR and PXR which may explain the negative effects of some drugs on hepatic lipid levels [14].
PXR Positive_regulation (induce) of Insig-1 in CAR
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.12
A functional SXR binding site was found in the Insig-1 promoter and it was suggested that Insig-1 induction by SXR could lead to decreased levels of active SREBP-1 and reduced triglyceride synthesis.
SXR Positive_regulation (induction) of Insig-1
2) Confidence 0.12 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0

General Comments

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