INT262205

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.11
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a11) endoplasmic reticulum (Cyp3a11) nucleus (Nr1i2)
DNA binding (Nr1i2)
Nr1i2 (Mus musculus)
Cyp3a11 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 39 97.08 Very High Very High Very High
Inflammation 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Van Bogaert's Disease 1 57.20 Quite High
Neurodegenerative Disease 1 54.48 Quite High
Targeted Disruption 17 43.12 Quite Low
Toxicity 4 15.12 Low Low
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Rickets 8 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of SXR by these sterol compounds induces CYP3A expression and provides an alternative pathway for sterol clearance in CYP27A1 null mice [Dussault et al., 2003; Goodwin et al., 2003].
Positive_regulation (Activation) of SXR Positive_regulation (induces) of Gene_expression (expression) of CYP3A
1) Confidence 0.33 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.11 Pain Relevance 0.38

General Comments

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