INT262212

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Insig1) nucleus (Nr1i2) DNA binding (Nr1i2)
lipid metabolic process (Insig1)
Nr1i2 (Mus musculus)
Insig1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 39 29.96 Quite Low
Inflammation 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 4 48.08 Quite Low
Targeted Disruption 17 41.68 Quite Low
Neurodegenerative Disease 1 36.68 Quite Low
Van Bogaert's Disease 1 35.52 Quite Low
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Rickets 8 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A functional SXR binding site was found in the Insig-1 promoter and it was suggested that Insig-1 induction by SXR could lead to decreased levels of active SREBP-1 and reduced triglyceride synthesis.
Positive_regulation (lead) of SXR Positive_regulation (induction) of Insig-1
1) Confidence 0.12 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0

General Comments

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