INT262215

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2, Dnajc7) unfolded protein binding (Dnajc7) protein folding (Dnajc7)
cytoskeleton (Dnajc7) DNA binding (Nr1i2) cytoplasm (Dnajc7)
Nr1i2 (Mus musculus)
Dnajc7 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 18 37.60 Quite Low
Bile 78 5.00 Very Low Very Low Very Low
Inflammation 34 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Crohn's disease 12 5.00 Very Low Very Low Very Low
antidepressant 6 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 2 99.60 Very High Very High Very High
Breast Cancer 16 81.04 Quite High
Inflammatory Bowel Disease 64 5.00 Very Low Very Low Very Low
Cancer 36 5.00 Very Low Very Low Very Low
Targeted Disruption 34 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Rickets 16 5.00 Very Low Very Low Very Low
Osteoporosis 14 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Saradhi et al. also could not find any association between CCRP complex and human SXR [Saradhi et al., 2005].
human SXR Neg (not) Binding (association) of CCRP
1) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0
In agreement with these studies, Negishi and co-workers showed that in the absence of ligand, SXR resides in a complex with CCRP and heat-shock proteins (HSPs), remaining in the cytoplasm until ligand binding which triggers nuclear translocation [Squires et al., 2004].
SXR Binding (complex) of CCRP associated with shock
2) Confidence 0.08 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.10 Pain Relevance 0

General Comments

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